3iyd

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[[Image:3iyd.png|left|200px]]
 
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==Three-dimensional EM structure of an intact activator-dependent transcription initiation complex==
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The line below this paragraph, containing "STRUCTURE_3iyd", creates the "Structure Box" on the page.
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<SX load='3iyd' size='340' side='right' viewer='molstar' caption='[[3iyd]], [[Resolution|resolution]] 19.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3iyd]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IYD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IYD FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 19.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CMP:ADENOSINE-3,5-CYCLIC-MONOPHOSPHATE'>CMP</scene></td></tr>
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{{STRUCTURE_3iyd| PDB=3iyd | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3iyd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iyd OCA], [https://pdbe.org/3iyd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3iyd RCSB], [https://www.ebi.ac.uk/pdbsum/3iyd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3iyd ProSAT]</span></td></tr>
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</table>
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===Three-dimensional EM structure of an intact activator-dependent transcription initiation complex===
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== Function ==
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[https://www.uniprot.org/uniprot/RPOA_ECOLI RPOA_ECOLI] DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit plays an important role in subunit assembly since its dimerization is the first step in the sequential assembly of subunits to form the holoenzyme.[HAMAP-Rule:MF_00059]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 19903881 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/iy/3iyd_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_19903881}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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[[3iyd]] is a 10 chain structure of [[RNA polymerase]] with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [http://en.wikipedia.org/wiki/Escherichia_coli_k-12 Escherichia coli k-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IYD OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3iyd ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[RNA polymerase]]
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*[[Catabolite gene activator protein 3D structures|Catabolite gene activator protein 3D structures]]
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*[[RNA polymerase 3D structures|RNA polymerase 3D structures]]
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==Reference==
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*[[Sigma factor 3D structures|Sigma factor 3D structures]]
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<ref group="xtra">PMID:019903881</ref><references group="xtra"/>
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__TOC__
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[[Category: DNA-directed RNA polymerase]]
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</SX>
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[[Category: Escherichia coli]]
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[[Category: Escherichia coli K-12]]
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[[Category: Escherichia coli k-12]]
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[[Category: Large Structures]]
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[[Category: Arnold, E.]]
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[[Category: Arnold E]]
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[[Category: Berman, H.]]
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[[Category: Berman H]]
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[[Category: Ebright, R H.]]
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[[Category: Ebright RH]]
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[[Category: Hudson, B P.]]
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[[Category: Hudson BP]]
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[[Category: Kim, Y.]]
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[[Category: Kim Y]]
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[[Category: Lara, S.]]
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[[Category: Lara S]]
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[[Category: Lawson, C L.]]
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[[Category: Lawson CL]]
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[[Category: Quispe, J.]]
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[[Category: Quispe J]]
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[[Category: Activator]]
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[[Category: Camp]]
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[[Category: Camp-binding]]
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[[Category: Camp-dependent]]
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[[Category: Cap]]
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[[Category: Class i]]
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[[Category: Crp]]
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[[Category: Dna]]
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[[Category: Dna-binding]]
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[[Category: Dna-directed rna polymerase]]
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[[Category: Holoenzyme]]
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[[Category: Initiation]]
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[[Category: Nucleotide-binding]]
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[[Category: Nucleotidyltransferase]]
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[[Category: Open complex]]
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[[Category: Prokaryotic]]
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[[Category: Rna polymerase]]
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[[Category: Sigma factor]]
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[[Category: Sigma70]]
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[[Category: Transcription]]
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[[Category: Transcription regulation]]
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[[Category: Transcription-dna complex]]
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[[Category: Transferase]]
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Current revision

Three-dimensional EM structure of an intact activator-dependent transcription initiation complex

3iyd, resolution 19.80Å

Proteopedia Page Contributors and Editors (what is this?)

OCA

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