2lgq

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[[Image:2lgq.png|left|200px]]
 
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==Human C30S/C59S-Cox17 mutant==
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The line below this paragraph, containing "STRUCTURE_2lgq", creates the "Structure Box" on the page.
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<StructureSection load='2lgq' size='340' side='right'caption='[[2lgq]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2lgq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LGQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LGQ FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lgq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lgq OCA], [https://pdbe.org/2lgq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lgq RCSB], [https://www.ebi.ac.uk/pdbsum/2lgq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lgq ProSAT]</span></td></tr>
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{{STRUCTURE_2lgq| PDB=2lgq | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/COX17_HUMAN COX17_HUMAN] Copper chaperone for cytochrome c oxidase (COX). Binds two copper ions and deliver them to the Cu(A) site of COX (By similarity).
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Human Cox17 is the mitochondrial copper chaperone responsible for supplying copper ions, through the assistance of Sco1, Sco2, and Cox11, to cytochrome c oxidase, the terminal enzyme of the mitochondrial energy-transducing respiratory chain. It consists of a coiled coil-helix-coiled coil-helix domain stabilized by two disulfide bonds and binds one copper(I) ion through a Cys-Cys motif. Here, the structures and the backbone mobilities of two Cox17 mutated forms with only one interhelical disulfide bond have been analyzed. It appears that the inner disulfide bond (formed by Cys-36 and Cys-45) stabilizes interhelical hydrophobic interactions, providing a structure with essentially the same structural dynamic properties of the mature Cox17 state. On the contrary, the external disulfide bond (formed by Cys-26 and Cys-55) generates a conformationally flexible alpha-helical protein, indicating that it is not able to stabilize interhelical packing contacts, but is important for structurally organizing the copper-binding site region.
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===Human C30S/C59S-Cox17 mutant===
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Functional role of two interhelical disulfide bonds in human cox17 protein from a structural perspective.,Banci L, Bertini I, Cefaro C, Ciofi-Baffoni S, Gallo A J Biol Chem. 2011 Sep 30;286(39):34382-90. Epub 2011 Aug 4. PMID:21816817<ref>PMID:21816817</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_21816817}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2lgq" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 21816817 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_21816817}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[2lgq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LGQ OCA].
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==Reference==
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<ref group="xtra">PMID:021816817</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Bertini, I.]]
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[[Category: Large Structures]]
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[[Category: Ciofi-Baffoni, S.]]
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[[Category: Bertini I]]
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[[Category: Gallo, A.]]
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[[Category: Ciofi-Baffoni S]]
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[[Category: Copper chaperone]]
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[[Category: Gallo A]]
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[[Category: Cytochrome c oxidase]]
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[[Category: Im]]
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[[Category: Metal transport]]
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[[Category: Mitochondrial protein]]
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Current revision

Human C30S/C59S-Cox17 mutant

PDB ID 2lgq

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