2l3i

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[[Image:2l3i.png|left|200px]]
 
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==Oxki4a, spider derived antimicrobial peptide==
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The line below this paragraph, containing "STRUCTURE_2l3i", creates the "Structure Box" on the page.
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<StructureSection load='2l3i' size='340' side='right'caption='[[2l3i]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2l3i]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Oxyopes_takobius Oxyopes takobius]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L3I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L3I FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l3i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l3i OCA], [https://pdbe.org/2l3i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l3i RCSB], [https://www.ebi.ac.uk/pdbsum/2l3i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l3i ProSAT]</span></td></tr>
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{{STRUCTURE_2l3i| PDB=2l3i | SCENE= }}
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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A unique 30-residue cationic peptide oxyopinin 4a (Oxt 4a) was identified in the venom of the lynx spider Oxyopes takobius (Oxyopidae). Oxt 4a contains a single N-terminally located disulfide bond, Cys4-Cys10, and is structurally different from any spider toxin studied so far. According to NMR findings, the peptide is disordered in water, but assumes a peculiar torpedo-like structure in detergent micelles. It features a C-terminal amphipathic alpha-helical segment (body; residues 12-25) and an N-terminal disulfide-stabilized loop (head; residues 1-11), and has an unusually high density of positive charge in the head region. Synthetic Oxt 4a was produced and shown to possess strong and broad-spectrum cytolytic and antimicrobial activity. cDNA cloning showed that the peptide is synthesized in the form of a conventional prepropeptide with an acidic prosequence. Unlike other arachnid toxins, Oxt 4a exhibits striking similarity with defense peptides from the skin of ranid frogs that contain the so-called Rana-box motif (a C-terminal disulfide-enclosed loop). Parallelism or convergence is apparent on several levels: the structure, function and biosynthesis of a lynx spider toxin are mirrored by those of Rana-box peptides from frogs. DATABASE: The protein sequence of oxyopinin 4a (Oxt 4a) has been submitted to the UniProt Knowledgebase (UniProtKB) under the accession number P86350. The coordinates and chemical shifts of Oxt 4a in complex with dodecylphosphocholine micelles have been deposited in the Protein Data Bank and Biological Magnetic Resonance Bank under the accession codes 2L3I and 17194, respectively. The nucleotide sequence encoding Oxt 4a has been submitted to the EMBL Nucleotide Sequence Database under the accession number FN997582.
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===Oxki4a, spider derived antimicrobial peptide===
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Novel lynx spider toxin shares common molecular architecture with defense peptides from frog skin.,Dubovskii PV, Vassilevski AA, Samsonova OV, Egorova NS, Kozlov SA, Feofanov AV, Arseniev AS, Grishin EV FEBS J. 2011 Sep 20. doi: 10.1111/j.1742-4658.2011.08361.x. PMID:21933345<ref>PMID:21933345</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2l3i" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 21933345 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_21933345}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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[[2l3i]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L3I OCA].
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[[Category: Oxyopes takobius]]
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[[Category: Arseniev AS]]
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==Reference==
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[[Category: Dubovskii PV]]
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<ref group="xtra">PMID:021933345</ref><references group="xtra"/>
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[[Category: Egorova NS]]
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[[Category: Arseniev, A S.]]
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[[Category: Feofanov AV]]
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[[Category: Dubovskii, P V.]]
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[[Category: Grishin EV]]
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[[Category: Egorova, N S.]]
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[[Category: Kozlov SA]]
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[[Category: Feofanov, A V.]]
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[[Category: Samsonova OV]]
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[[Category: Grishin, E V.]]
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[[Category: Vassilevski AA]]
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[[Category: Kozlov, S A.]]
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[[Category: Samsonova, O V.]]
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[[Category: Vassilevski, A A.]]
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[[Category: Antimicrobial peptide]]
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[[Category: Antimicrobial protein]]
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Current revision

Oxki4a, spider derived antimicrobial peptide

PDB ID 2l3i

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