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3p5j

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[[Image:3p5j.png|left|200px]]
 
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==The structure of the human RNase H2 complex defines key interaction interfaces relevant to enzyme function and human disease==
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The line below this paragraph, containing "STRUCTURE_3p5j", creates the "Structure Box" on the page.
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<StructureSection load='3p5j' size='340' side='right'caption='[[3p5j]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3p5j]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P5J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3P5J FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3p5j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p5j OCA], [https://pdbe.org/3p5j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3p5j RCSB], [https://www.ebi.ac.uk/pdbsum/3p5j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3p5j ProSAT]</span></td></tr>
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{{STRUCTURE_3p5j| PDB=3p5j | SCENE= }}
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</table>
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== Function ==
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===The structure of the human RNase H2 complex defines key interaction interfaces relevant to enzyme function and human disease===
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[https://www.uniprot.org/uniprot/RNH2A_MOUSE RNH2A_MOUSE] Catalytic subunit of RNase HII, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.<ref>PMID:19923215</ref>
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The line below this paragraph, {{ABSTRACT_PUBMED_19923215}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 19923215 is the PubMed ID number.
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{{ABSTRACT_PUBMED_19923215}}
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==About this Structure==
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[[3p5j]] is a 3 chain structure of [[Ribonuclease]] with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P5J OCA].
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==See Also==
==See Also==
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*[[Ribonuclease]]
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*[[Ribonuclease 3D structures|Ribonuclease 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:019923215</ref><ref group="xtra">PMID:021177854</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Ribonuclease H]]
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[[Category: Bubeck D]]
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[[Category: Bubeck, D.]]
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[[Category: Graham SC]]
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[[Category: Graham, S C.]]
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[[Category: Jones EY]]
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[[Category: Jones, E Y.]]
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[[Category: Hydrolase-replication complex]]
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[[Category: Nuclease that cleaves rna/dna hybrid]]
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[[Category: Nucleus]]
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[[Category: Rnase h2 fold]]
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[[Category: Triple beta-barrel]]
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Current revision

The structure of the human RNase H2 complex defines key interaction interfaces relevant to enzyme function and human disease

PDB ID 3p5j

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