3rzu

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[[Image:3rzu.png|left|200px]]
 
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==The Crystal Structure of the Catalytic Domain of AMSH==
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The line below this paragraph, containing "STRUCTURE_3rzu", creates the "Structure Box" on the page.
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<StructureSection load='3rzu' size='340' side='right'caption='[[3rzu]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3rzu]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RZU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RZU FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_3rzu| PDB=3rzu | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rzu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rzu OCA], [https://pdbe.org/3rzu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rzu RCSB], [https://www.ebi.ac.uk/pdbsum/3rzu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rzu ProSAT]</span></td></tr>
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</table>
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===The Crystal Structure of the Catalytic Domain of AMSH===
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== Disease ==
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[https://www.uniprot.org/uniprot/STABP_HUMAN STABP_HUMAN] Microcephaly-capillary malformation syndrome. The disease is caused by mutations affecting the gene represented in this entry.
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== Function ==
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[https://www.uniprot.org/uniprot/STABP_HUMAN STABP_HUMAN] Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains (By similarity). Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF. Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7. Has a key role in regulation of cell surface receptor-mediated endocytosis and ubiquitin-dependent sorting of receptors to lysosomes. Endosomal localization of STAMBP is required for efficient EGFR degradation but not for its internalization (By similarity). Involved in the negative regulation of PI3K-AKT-mTOR and RAS-MAP signaling pathways.<ref>PMID:10383417</ref> <ref>PMID:11483516</ref> <ref>PMID:15314065</ref> <ref>PMID:17261583</ref> <ref>PMID:23542699</ref>
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The line below this paragraph, {{ABSTRACT_PUBMED_21888914}}, adds the Publication Abstract to the page
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== References ==
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(as it appears on PubMed at http://www.pubmed.gov), where 21888914 is the PubMed ID number.
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<references/>
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__TOC__
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{{ABSTRACT_PUBMED_21888914}}
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</StructureSection>
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==About this Structure==
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[[3rzu]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RZU OCA].
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==Reference==
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<ref group="xtra">PMID:021888914</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Das, C.]]
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[[Category: Large Structures]]
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[[Category: Davies, C W.]]
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[[Category: Das C]]
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[[Category: Endosome-associated deubiquitinating enzyme]]
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[[Category: Davies CW]]
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[[Category: Hydrolase]]
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[[Category: Stam]]
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[[Category: Ubiquitin hydrolase]]
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Current revision

The Crystal Structure of the Catalytic Domain of AMSH

PDB ID 3rzu

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OCA

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