2y7j

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[[Image:2y7j.png|left|200px]]
 
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==Structure of human phosphorylase kinase, gamma 2==
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The line below this paragraph, containing "STRUCTURE_2y7j", creates the "Structure Box" on the page.
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<StructureSection load='2y7j' size='340' side='right'caption='[[2y7j]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2y7j]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y7J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Y7J FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=B49:N-[2-(DIETHYLAMINO)ETHYL]-5-[(Z)-(5-FLUORO-2-OXO-1,2-DIHYDRO-3H-INDOL-3-YLIDENE)METHYL]-2,4-DIMETHYL-1H-PYRROLE-3-CARBOXAMIDE'>B49</scene></td></tr>
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{{STRUCTURE_2y7j| PDB=2y7j | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2y7j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y7j OCA], [https://pdbe.org/2y7j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2y7j RCSB], [https://www.ebi.ac.uk/pdbsum/2y7j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2y7j ProSAT]</span></td></tr>
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</table>
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===STRUCTURE OF HUMAN PHOSPHORYLASE KINASE, GAMMA 2===
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== Disease ==
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[https://www.uniprot.org/uniprot/PHKG2_HUMAN PHKG2_HUMAN] Glycogen storage disease due to liver phosphorylase kinase deficiency. The disease is caused by mutations affecting the gene represented in this entry.
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== Function ==
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==About this Structure==
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[https://www.uniprot.org/uniprot/PHKG2_HUMAN PHKG2_HUMAN] Catalytic subunit of the phosphorylase b kinase (PHK), which mediates the neural and hormonal regulation of glycogen breakdown (glycogenolysis) by phosphorylating and thereby activating glycogen phosphorylase. May regulate glycogeneolysis in the testis. In vitro, phosphorylates PYGM (By similarity).<ref>PMID:10487978</ref>
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[[2y7j]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y7J OCA].
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Phosphorylase kinase]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Arrowsmith CH]]
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[[Category: Berridge, G.]]
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[[Category: Berridge G]]
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[[Category: Bountra, C.]]
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[[Category: Bountra C]]
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[[Category: Brenner, B.]]
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[[Category: Brenner B]]
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[[Category: Burgess-Brown, N.]]
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[[Category: Burgess-Brown N]]
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[[Category: Che, K H.]]
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[[Category: Che KH]]
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[[Category: Delft, F Von.]]
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[[Category: Edwards AM]]
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[[Category: Edwards, A M.]]
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[[Category: Elkins JM]]
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[[Category: Elkins, J M.]]
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[[Category: Fedorov O]]
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[[Category: Fedorov, O.]]
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[[Category: Knapp S]]
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[[Category: Knapp, S.]]
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[[Category: Krojer T]]
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[[Category: Krojer, T.]]
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[[Category: Muniz JRC]]
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[[Category: Muniz, J R.C.]]
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[[Category: Rellos P]]
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[[Category: Rellos, P.]]
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[[Category: Savitsky P]]
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[[Category: Savitsky, P.]]
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[[Category: Shrestha A]]
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[[Category: Shrestha, A.]]
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[[Category: Vollmar M]]
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[[Category: Vollmar, M.]]
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[[Category: Wang J]]
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[[Category: Wang, J.]]
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[[Category: Weigelt J]]
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[[Category: Weigelt, J.]]
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[[Category: Von Delft F]]
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[[Category: Transferase]]
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Current revision

Structure of human phosphorylase kinase, gamma 2

PDB ID 2y7j

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