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3axy

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[[Image:3axy.png|left|200px]]
 
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==Structure of Florigen Activation Complex Consisting of Rice Florigen Hd3a, 14-3-3 Protein GF14 and Rice FD Homolog OsFD1==
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The line below this paragraph, containing "STRUCTURE_3axy", creates the "Structure Box" on the page.
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<StructureSection load='3axy' size='340' side='right'caption='[[3axy]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3axy]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryza_sativa_Japonica_Group Oryza sativa Japonica Group]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AXY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3AXY FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
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{{STRUCTURE_3axy| PDB=3axy | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3axy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3axy OCA], [https://pdbe.org/3axy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3axy RCSB], [https://www.ebi.ac.uk/pdbsum/3axy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3axy ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/HD3A_ORYSJ HD3A_ORYSJ] Probable mobile flower-promoting signal (florigen) that moves from the leaf to the shoot apical meristem (SAM) and induces flowering. Promotes the transition from vegetative growth to flowering downstream of HD1 and EHD1 under short day (SD) conditions. Acts upstream of MADS14 and MADS15.<ref>PMID:12407188</ref> <ref>PMID:17446351</ref> <ref>PMID:18223202</ref> <ref>PMID:19762423</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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'Florigen' was proposed 75 years ago to be synthesized in the leaf and transported to the shoot apex, where it induces flowering. Only recently have genetic and biochemical studies established that florigen is encoded by FLOWERING LOCUS T (FT), a gene that is universally conserved in higher plants. Nonetheless, the exact function of florigen during floral induction remains poorly understood and receptors for florigen have not been identified. Here we show that the rice FT homologue Hd3a interacts with 14-3-3 proteins in the apical cells of shoots, yielding a complex that translocates to the nucleus and binds to the Oryza sativa (Os)FD1 transcription factor, a rice homologue of Arabidopsis thaliana FD. The resultant ternary 'florigen activation complex' (FAC) induces transcription of OsMADS15, a homologue of A. thaliana APETALA1 (AP1), which leads to flowering. We have determined the 2.4 A crystal structure of rice FAC, which provides a mechanistic basis for florigen function in flowering. Our results indicate that 14-3-3 proteins act as intracellular receptors for florigen in shoot apical cells, and offer new approaches to manipulate flowering in various crops and trees.
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===Structure of Florigen Activation Complex Consisting of Rice Florigen Hd3a, 14-3-3 Protein GF14 and Rice FD Homolog OsFD1===
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14-3-3 proteins act as intracellular receptors for rice Hd3a florigen.,Taoka K, Ohki I, Tsuji H, Furuita K, Hayashi K, Yanase T, Yamaguchi M, Nakashima C, Purwestri YA, Tamaki S, Ogaki Y, Shimada C, Nakagawa A, Kojima C, Shimamoto K Nature. 2011 Jul 31;476(7360):332-5. doi: 10.1038/nature10272. PMID:21804566<ref>PMID:21804566</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3axy" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[14-3-3 protein 3D structures|14-3-3 protein 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 21804566 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_21804566}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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[[3axy]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryza_sativa_japonica_group Oryza sativa japonica group]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AXY OCA].
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[[Category: Oryza sativa Japonica Group]]
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[[Category: Furuita K]]
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==Reference==
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[[Category: Hayashi K]]
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<ref group="xtra">PMID:021804566</ref><references group="xtra"/>
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[[Category: Kojima C]]
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[[Category: Oryza sativa japonica group]]
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[[Category: Nakagawa A]]
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[[Category: Furuita, K.]]
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[[Category: Ohki I]]
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[[Category: Hayashi, K.]]
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[[Category: Shimamoto K]]
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[[Category: Kojima, C.]]
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[[Category: Taoka K]]
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[[Category: Nakagawa, A.]]
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[[Category: Tsuji H]]
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[[Category: Ohki, I.]]
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[[Category: Shimamoto, K.]]
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[[Category: Taoka, K.]]
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[[Category: Tsuji, H.]]
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[[Category: 14-3-3 protein]]
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[[Category: Bzip protein]]
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[[Category: Dna binding]]
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[[Category: Floral induction]]
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[[Category: Nucleus]]
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[[Category: Phosphatidylethanolamine-binding protein]]
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[[Category: Phosphorylation]]
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[[Category: Signaling protein]]
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[[Category: Signaling protein-protein binding complex]]
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[[Category: Transcriptional activator]]
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Current revision

Structure of Florigen Activation Complex Consisting of Rice Florigen Hd3a, 14-3-3 Protein GF14 and Rice FD Homolog OsFD1

PDB ID 3axy

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