1hfk

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[[Image:1hfk.png|left|200px]]
 
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==Asparaginase from Erwinia chrysanthemi, hexagonal form with weak sulfate==
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The line below this paragraph, containing "STRUCTURE_1hfk", creates the "Structure Box" on the page.
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<StructureSection load='1hfk' size='340' side='right'caption='[[1hfk]], [[Resolution|resolution]] 2.17&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1hfk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Dickeya_chrysanthemi Dickeya chrysanthemi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HFK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HFK FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.17&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_1hfk| PDB=1hfk | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hfk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hfk OCA], [https://pdbe.org/1hfk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hfk RCSB], [https://www.ebi.ac.uk/pdbsum/1hfk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hfk ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ASPG_DICCH ASPG_DICCH]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hf/1hfk_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1hfk ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Quasi-enantiomorphic crystals of the Y25F mutant of Escherichia coli L-asparaginase and of the native Erwinia chrysanthemi L-asparaginase were obtained in the hexagonal space groups P6(5)22 and P6(1)22, respectively. The structures of these highly homologous enzymes were solved by molecular replacement and were refined with data extending to 2.2-2.5 A. These structures were compared with each other, as well as with other L-asparaginase structures previously observed with different crystal packing. It is concluded that the observed phenomenon, which is rare, was most likely to have arisen by chance.
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===ASPARAGINASE FROM ERWINIA CHRYSANTHEMI, HEXAGONAL FORM WITH WEAK SULFATE===
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Structures of two highly homologous bacterial L-asparaginases: a case of enantiomorphic space groups.,Jaskolski M, Kozak M, Lubkowski J, Palm G, Wlodawer A Acta Crystallogr D Biol Crystallogr. 2001 Mar;57(Pt 3):369-77. PMID:11223513<ref>PMID:11223513</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1hfk" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_11223513}}, adds the Publication Abstract to the page
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*[[Asparaginase 3D structures|Asparaginase 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 11223513 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_11223513}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Dickeya chrysanthemi]]
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[[1hfk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Erwinia_chrysanthemi Erwinia chrysanthemi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HFK OCA].
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[[Category: Large Structures]]
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[[Category: Jaskolski M]]
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==Reference==
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[[Category: Kozak M]]
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<ref group="xtra">PMID:011223513</ref><ref group="xtra">PMID:008434007</ref><ref group="xtra">PMID:008348975</ref><ref group="xtra">PMID:017168537</ref><references group="xtra"/>
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[[Category: Lubkowski J]]
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[[Category: Asparaginase]]
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[[Category: Palm GJ]]
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[[Category: Erwinia chrysanthemi]]
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[[Category: Wlodawer A]]
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[[Category: Jaskolski, M.]]
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[[Category: Kozak, M.]]
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[[Category: Lubkowski, J.]]
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[[Category: Palm, G J.]]
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[[Category: Wlodawer, A.]]
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[[Category: Hydrolase]]
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Current revision

Asparaginase from Erwinia chrysanthemi, hexagonal form with weak sulfate

PDB ID 1hfk

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