2wvg

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[[Image:2wvg.png|left|200px]]
 
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==Structural insights into the pre-reaction state of pyruvate decarboxylase from Zymomonas mobilis==
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The line below this paragraph, containing "STRUCTURE_2wvg", creates the "Structure Box" on the page.
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<StructureSection load='2wvg' size='340' side='right'caption='[[2wvg]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2wvg]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Zymomonas_mobilis Zymomonas mobilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WVG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WVG FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=F:FLUORIDE+ION'>F</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TPU:2-{1-[(4-AMINO-2-METHYLPYRIMIDIN-5-YL)METHYL]-5-METHYL-1H-1,2,3-TRIAZOL-4-YL}ETHYL+TRIHYDROGEN+DIPHOSPHATE'>TPU</scene></td></tr>
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{{STRUCTURE_2wvg| PDB=2wvg | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wvg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wvg OCA], [https://pdbe.org/2wvg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wvg RCSB], [https://www.ebi.ac.uk/pdbsum/2wvg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wvg ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PDC_ZYMMO PDC_ZYMMO]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wv/2wvg_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2wvg ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Pyruvate decarboxylase (PDC) uses thiamine diphosphate as an essential cofactor to catalyze the formation of acetaldehyde on the pathway of ethanol synthesis. Here we report the crystallographic image of a prereaction intermediate of a bacterial pyruvate decarboxylase prepared by cocrystallizing the enzyme with pyruvate and a stable analogue of the cofactor's activated ylid form. A second crystal structure of PDC in complex with fluoride shows that the ion organizes a water molecule that occludes the pyruvate binding site, accounting for the inhibitory effect of the halide. Also reported is a structure of the cofactor-free apo form, which when compared to the structure of the holo form indicates how thiamine diphosphate organizes the active site pocket of pyruvate decarboxylase to support catalysis. Guided by the structural and enzymatic data, we propose roles for several key residues in the catalytic mechanism.
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===STRUCTURAL INSIGHTS INTO THE PRE-REACTION STATE OF PYRUVATE DECARBOXYLASE FROM ZYMOMONAS MOBILIS===
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Structural Insights into the Prereaction State of Pyruvate Decarboxylase from Zymomonas mobilis .,Pei XY, Erixon KM, Luisi BF, Leeper FJ Biochemistry. 2010 Feb 5. PMID:20099870<ref>PMID:20099870</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_20099870}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2wvg" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 20099870 is the PubMed ID number.
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{{ABSTRACT_PUBMED_20099870}}
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==About this Structure==
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[[2wvg]] is a 4 chain structure of [[Pyruvate decarboxylase]] with sequence from [http://en.wikipedia.org/wiki/Zymomonas_mobilis Zymomonas mobilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WVG OCA].
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==See Also==
==See Also==
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*[[Pyruvate decarboxylase]]
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*[[Pyruvate decarboxylase|Pyruvate decarboxylase]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:020099870</ref><references group="xtra"/>
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__TOC__
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[[Category: Pyruvate decarboxylase]]
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Zymomonas mobilis]]
[[Category: Zymomonas mobilis]]
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[[Category: Erixon, K.]]
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[[Category: Erixon K]]
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[[Category: Leeper, F J.]]
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[[Category: Leeper FJ]]
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[[Category: Luisi, B F.]]
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[[Category: Luisi BF]]
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[[Category: Pei, X Y.]]
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[[Category: Pei XY]]
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[[Category: Alcohol fermentation]]
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[[Category: Flavoprotein]]
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[[Category: Lyase]]
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[[Category: Metal-binding]]
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[[Category: Thiamine diphosphate]]
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Current revision

Structural insights into the pre-reaction state of pyruvate decarboxylase from Zymomonas mobilis

PDB ID 2wvg

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