3tp0

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'''Unreleased structure'''
 
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The entry 3tp0 is ON HOLD until Paper Publication
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==Structural activation of the transcriptional repressor EthR from M. tuberculosis by single amino-acid change mimicking natural and synthetic ligands==
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<StructureSection load='3tp0' size='340' side='right'caption='[[3tp0]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3tp0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TP0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TP0 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FO5:3-OXO-3-{4-[3-(THIOPHEN-2-YL)-1,2,4-OXADIAZOL-5-YL]PIPERIDIN-1-YL}PROPANENITRILE'>FO5</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tp0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tp0 OCA], [https://pdbe.org/3tp0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tp0 RCSB], [https://www.ebi.ac.uk/pdbsum/3tp0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tp0 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ETHR_MYCTU ETHR_MYCTU] Involved in the repression of the monooxygenase EthA which is responsible of the formation of the active metabolite of ethionamide (ETH).<ref>PMID:10869356</ref> <ref>PMID:10944230</ref>
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Authors: Carette, X., Blondiaux, N., Willery, E., Hoos, S., Lecat-Guillet, N., Lens, Z., Wohlkonig, A., Wintjens, R., Soror, S., Fr nois, F., Diri , B., Villeret, V., England, P., Lippens, G., Deprez, B., Locht, C., Willand, N., Baulard, A.
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==See Also==
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*[[Tetracycline repressor protein 3D structures|Tetracycline repressor protein 3D structures]]
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Description: Structural activation of the transcriptional repressor EthR from M. tuberculosis by single amino-acid change mimicking natural and synthetic ligands
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Mycobacterium tuberculosis]]
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[[Category: Baulard A]]
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[[Category: Blondiaux N]]
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[[Category: Carette X]]
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[[Category: Deprez B]]
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[[Category: Diri B]]
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[[Category: England P]]
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[[Category: Fr nois F]]
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[[Category: Hoos S]]
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[[Category: Lecat-Guillet N]]
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[[Category: Lens Z]]
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[[Category: Lippens G]]
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[[Category: Locht C]]
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[[Category: Soror S]]
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[[Category: Villeret V]]
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[[Category: Willand N]]
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[[Category: Willery E]]
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[[Category: Wintjens R]]
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[[Category: Wohlkonig A]]

Current revision

Structural activation of the transcriptional repressor EthR from M. tuberculosis by single amino-acid change mimicking natural and synthetic ligands

PDB ID 3tp0

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