3u2o
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 3u2o is ON HOLD until Paper Publication Authors: Lozoya, E., Segarra, V., Erra, M., Wenzkowski, C., Jestel, A., Krapp, S., Blaesse, M. Description:...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Dihydroorotate Dehydrogenase (DHODH) crystal structure in complex with small molecule inhibitor== | |
| + | <StructureSection load='3u2o' size='340' side='right'caption='[[3u2o]], [[Resolution|resolution]] 2.18Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3u2o]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U2O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3U2O FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.18Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=03U:METHYL+4-{[(2Z)-2-CYANO-3-HYDROXYPENT-2-ENOYL]AMINO}-4-FLUOROBIPHENYL-2-CARBOXYLATE'>03U</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=ORO:OROTIC+ACID'>ORO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3u2o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u2o OCA], [https://pdbe.org/3u2o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3u2o RCSB], [https://www.ebi.ac.uk/pdbsum/3u2o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3u2o ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/PYRD_HUMAN PYRD_HUMAN] Defects in DHODH are the cause of postaxial acrofacial dysostosis (POADS) [MIM:[https://omim.org/entry/263750 263750]; also known as Miller syndrome. POADS is characterized by severe micrognathia, cleft lip and/or palate, hypoplasia or aplasia of the posterior elements of the limbs, coloboma of the eyelids and supernumerary nipples. POADS is a very rare disorder: only 2 multiplex families, each consisting of 2 affected siblings born to unaffected, nonconsanguineous parents, have been described among a total of around 30 reported cases.<ref>PMID:19915526</ref> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PYRD_HUMAN PYRD_HUMAN] Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. | ||
| - | + | ==See Also== | |
| - | + | *[[Dihydroorotate dehydrogenase 3D structures|Dihydroorotate dehydrogenase 3D structures]] | |
| - | + | == References == | |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Blaesse M]] | ||
| + | [[Category: Erra M]] | ||
| + | [[Category: Jestel A]] | ||
| + | [[Category: Krapp S]] | ||
| + | [[Category: Lozoya E]] | ||
| + | [[Category: Segarra V]] | ||
| + | [[Category: Wenzkowski C]] | ||
Current revision
Dihydroorotate Dehydrogenase (DHODH) crystal structure in complex with small molecule inhibitor
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Categories: Homo sapiens | Large Structures | Blaesse M | Erra M | Jestel A | Krapp S | Lozoya E | Segarra V | Wenzkowski C
