3u2z

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'''Unreleased structure'''
 
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The entry 3u2z is ON HOLD until Paper Publication
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==Activator-Bound Structure of Human Pyruvate Kinase M2==
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<StructureSection load='3u2z' size='340' side='right'caption='[[3u2z]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3u2z]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U2Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3U2Z FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=07T:6-(3-AMINOBENZYL)-4-METHYL-2-METHYLSULFINYL-4,6-DIHYDRO-5H-THIENO[2,3 4,5]PYRROLO[2,3-D]PYRIDAZIN-5-ONE'>07T</scene>, <scene name='pdbligand=FBP:BETA-FRUCTOSE-1,6-DIPHOSPHATE'>FBP</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3u2z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u2z OCA], [https://pdbe.org/3u2z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3u2z RCSB], [https://www.ebi.ac.uk/pdbsum/3u2z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3u2z ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/KPYM_HUMAN KPYM_HUMAN] Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio betwween the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival.<ref>PMID:17308100</ref> <ref>PMID:18191611</ref> <ref>PMID:21620138</ref>
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Authors: Hong, B., Dimov, S., Tempel, W., Auld, D., Thomas, C., Boxer, M., Jianq, J.-K., Skoumbourdis, A., Min, S., Southall, N., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Inglese, J., Park, H., Structural Genomics Consortium (SGC)
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==See Also==
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*[[Pyruvate kinase 3D structures|Pyruvate kinase 3D structures]]
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Description: Activator-Bound Structure of Human Pyruvate Kinase M2
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith CH]]
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[[Category: Auld D]]
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[[Category: Bountra C]]
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[[Category: Boxer M]]
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[[Category: Dimov S]]
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[[Category: Edwards AM]]
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[[Category: Hong B]]
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[[Category: Inglese J]]
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[[Category: Jianq J-K]]
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[[Category: Min S]]
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[[Category: Park H]]
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[[Category: Skoumbourdis A]]
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[[Category: Southall N]]
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[[Category: Tempel W]]
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[[Category: Thomas C]]
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[[Category: Weigelt J]]

Current revision

Activator-Bound Structure of Human Pyruvate Kinase M2

PDB ID 3u2z

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