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3u7x
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 3u7x is ON HOLD Authors: Siddiqui, N., Tempel, W., Nedyalkova, L., Wernimont, A.K., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Borde...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the human eIF4E-4EBP1 peptide complex without cap== | |
| + | <StructureSection load='3u7x' size='340' side='right'caption='[[3u7x]], [[Resolution|resolution]] 2.10Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3u7x]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3smu 3smu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U7X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3U7X FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3u7x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u7x OCA], [https://pdbe.org/3u7x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3u7x RCSB], [https://www.ebi.ac.uk/pdbsum/3u7x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3u7x ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/IF4E_HUMAN IF4E_HUMAN] Its translation stimulation activity is repressed by binding to the complex CYFIP1-FMR1 (By similarity). Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap.<ref>PMID:16271312</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Eukaryotic initiation factor 3D structures|Eukaryotic initiation factor 3D structures]] | |
| - | + | == References == | |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Arrowsmith CH]] | ||
| + | [[Category: Borden KLB]] | ||
| + | [[Category: Bountra C]] | ||
| + | [[Category: Edwards AM]] | ||
| + | [[Category: Nedyalkova L]] | ||
| + | [[Category: Park H]] | ||
| + | [[Category: Siddiqui N]] | ||
| + | [[Category: Tempel W]] | ||
| + | [[Category: Weigelt J]] | ||
| + | [[Category: Wernimont AK]] | ||
Current revision
Crystal structure of the human eIF4E-4EBP1 peptide complex without cap
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Categories: Homo sapiens | Large Structures | Arrowsmith CH | Borden KLB | Bountra C | Edwards AM | Nedyalkova L | Park H | Siddiqui N | Tempel W | Weigelt J | Wernimont AK
