3sn7

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[[Image:3sn7.png|left|200px]]
 
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==Highly Potent, Selective, and Orally Active Phosphodiestarase 10A Inhibitors==
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The line below this paragraph, containing "STRUCTURE_3sn7", creates the "Structure Box" on the page.
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<StructureSection load='3sn7' size='340' side='right'caption='[[3sn7]], [[Resolution|resolution]] 1.82&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3sn7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SN7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SN7 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.82&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=540:8-FLUORO-6-METHOXY-3,4-DIMETHYL-1-(3-METHYLPYRIDIN-4-YL)IMIDAZO[1,5-A]QUINOXALINE'>540</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_3sn7| PDB=3sn7 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3sn7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sn7 OCA], [https://pdbe.org/3sn7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3sn7 RCSB], [https://www.ebi.ac.uk/pdbsum/3sn7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3sn7 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PDE10_HUMAN PDE10_HUMAN] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:17389385</ref>
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===Highly Potent, Selective, and Orally Active Phosphodiestarase 10A Inhibitors===
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==See Also==
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*[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]]
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== References ==
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 21988093 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_21988093}}
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==About this Structure==
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[[3sn7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SN7 OCA].
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==Reference==
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<ref group="xtra">PMID:021988093</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Parris, K D.]]
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[[Category: Large Structures]]
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[[Category: Hydrolase]]
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[[Category: Parris KD]]
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[[Category: Hydrolase inhibitor]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Zn binding]]
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Current revision

Highly Potent, Selective, and Orally Active Phosphodiestarase 10A Inhibitors

PDB ID 3sn7

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