2y6w

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (10:46, 20 December 2023) (edit) (undo)
 
(6 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2y6w.png|left|200px]]
 
-
<!--
+
==Structure of a Bcl-w dimer==
-
The line below this paragraph, containing "STRUCTURE_2y6w", creates the "Structure Box" on the page.
+
<StructureSection load='2y6w' size='340' side='right'caption='[[2y6w]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[2y6w]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y6W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Y6W FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
-
{{STRUCTURE_2y6w| PDB=2y6w | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2y6w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y6w OCA], [https://pdbe.org/2y6w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2y6w RCSB], [https://www.ebi.ac.uk/pdbsum/2y6w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2y6w ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/B2CL2_HUMAN B2CL2_HUMAN] Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX.<ref>PMID:8761287</ref>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
The prosurvival and proapoptotic proteins of the BCL-2 family share a similar three-dimensional fold despite their opposing functions. However, many biochemical studies highlight the requirement for conformational changes for the functioning of both types of proteins, although structural data to support such changes remain elusive. Here, we describe the X-ray structure of dimeric BCL-W that reveals a major conformational change involving helices alpha3 and alpha4 hinging away from the core of the protein. Biochemical and functional studies reveal that the alpha4-alpha5 hinge region is required for dimerization of BCL-W, and functioning of both pro- and antiapoptotic BCL-2 proteins. Hence, this structure reveals a conformational flexibility not seen in previous BCL-2 protein structures and provides insights into how these regulators of apoptosis can change conformation to exert their function.
-
===STRUCTURE OF A BCL-W DIMER===
+
Crystal Structure of a BCL-W Domain-Swapped Dimer: Implications for the Function of BCL-2 Family Proteins.,Lee EF, Dewson G, Smith BJ, Evangelista M, Pettikiriarachchi A, Dogovski C, Perugini MA, Colman PM, Fairlie WD Structure. 2011 Oct 12;19(10):1467-76. PMID:22000515<ref>PMID:22000515</ref>
 +
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 +
</div>
 +
<div class="pdbe-citations 2y6w" style="background-color:#fffaf0;"></div>
-
<!--
+
==See Also==
-
The line below this paragraph, {{ABSTRACT_PUBMED_22000515}}, adds the Publication Abstract to the page
+
*[[B-cell lymphoma proteins 3D structures|B-cell lymphoma proteins 3D structures]]
-
(as it appears on PubMed at http://www.pubmed.gov), where 22000515 is the PubMed ID number.
+
== References ==
-
-->
+
<references/>
-
{{ABSTRACT_PUBMED_22000515}}
+
__TOC__
-
 
+
</StructureSection>
-
==About this Structure==
+
-
[[2y6w]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y6W OCA].
+
-
 
+
-
==Reference==
+
-
<ref group="xtra">PMID:022000515</ref><references group="xtra"/>
+
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Colman, P M.]]
+
[[Category: Large Structures]]
-
[[Category: Dogovski, C.]]
+
[[Category: Colman PM]]
-
[[Category: Evangelista, M.]]
+
[[Category: Dogovski C]]
-
[[Category: Fairlie, W D.]]
+
[[Category: Evangelista M]]
-
[[Category: Lee, E F.]]
+
[[Category: Fairlie WD]]
-
[[Category: Perugini, M A.]]
+
[[Category: Lee EF]]
-
[[Category: Pettikiriarachchi, A.]]
+
[[Category: Perugini MA]]
-
[[Category: Apoptosis]]
+
[[Category: Pettikiriarachchi A]]

Current revision

Structure of a Bcl-w dimer

PDB ID 2y6w

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2y6w"
Personal tools