1mrp

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (07:47, 14 February 2024) (edit) (undo)
 
(15 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1mrp.jpg|left|200px]]<br /><applet load="1mrp" size="350" color="white" frame="true" align="right" spinBox="true"
 
-
caption="1mrp, resolution 1.6&Aring;" />
 
-
'''FERRIC-BINDING PROTEIN FROM HAEMOPHILUS INFLUENZAE'''<br />
 
-
==Overview==
+
==FERRIC-BINDING PROTEIN FROM HAEMOPHILUS INFLUENZAE==
-
The first crystal structure of the iron-transporter ferric ion-binding, protein from Haemophilus influenzae (hFBP), at 1.6 A resolution, reveals, the structural basis for iron uptake and transport required by several, important bacterial pathogens. Paradoxically, although hFBP belongs to a, protein superfamily which includes human transferrin, iron binding in hFBP, and transferrin appears to have developed independently by convergent, evolution. Structural comparison of hFBP with other prokaryotic, periplasmic transport proteins and the eukaryotic transferrins suggests, that these proteins are related by divergent evolution from an, anion-binding common ancestor, not from an iron-binding ancestor. The iron, binding site of hFBP incorporates a water and an exogenous phosphate ion, as iron ligands and exhibits nearly ideal octahedral metal coordination., FBP is highly conserved, required for virulence, and is a nodal point for, free iron uptake in several Gram-negative pathogenic bacteria, thus, providing a potential target for broad-spectrum antibacterial drug design, against human pathogens such as H. influenzae, Neisseria gonorrhoeae, and, Neisseria meningitidis.
+
<StructureSection load='1mrp' size='340' side='right'caption='[[1mrp]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[1mrp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Haemophilus_influenzae Haemophilus influenzae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MRP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MRP FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mrp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mrp OCA], [https://pdbe.org/1mrp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mrp RCSB], [https://www.ebi.ac.uk/pdbsum/1mrp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mrp ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/FBPA_HAEIN FBPA_HAEIN] Part of the ABC transporter complex FbpABC (TC 3.A.1.10.1) involved in Fe(3+) ions import. This protein specifically binds Fe(3+) and is involved in its transmembrane transport (By similarity).
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mr/1mrp_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1mrp ConSurf].
 +
<div style="clear:both"></div>
-
==About this Structure==
+
==See Also==
-
1MRP is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Haemophilus_influenzae Haemophilus influenzae] with <scene name='pdbligand=FE:'>FE</scene> and <scene name='pdbligand=PO4:'>PO4</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Sites: <scene name='pdbsite=FE:Ferric+Ion+Binding+Site'>FE</scene> and <scene name='pdbsite=PO4:Phosphate+Ion+Binding+Site'>PO4</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MRP OCA].
+
*[[Ferric-binding protein|Ferric-binding protein]]
-
 
+
__TOC__
-
==Reference==
+
</StructureSection>
-
Structure of Haemophilus influenzae Fe(+3)-binding protein reveals convergent evolution within a superfamily., Bruns CM, Nowalk AJ, Arvai AS, McTigue MA, Vaughan KG, Mietzner TA, McRee DE, Nat Struct Biol. 1997 Nov;4(11):919-24. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9360608 9360608]
+
[[Category: Haemophilus influenzae]]
[[Category: Haemophilus influenzae]]
-
[[Category: Single protein]]
+
[[Category: Large Structures]]
-
[[Category: Arvai, A.S.]]
+
[[Category: Arvai AS]]
-
[[Category: Bruns, C.M.]]
+
[[Category: Bruns CM]]
-
[[Category: Mcree, D.E.]]
+
[[Category: Mcree DE]]
-
[[Category: Mctigue, M.A.]]
+
[[Category: Mctigue MA]]
-
[[Category: Mietzner, T.A.]]
+
[[Category: Mietzner TA]]
-
[[Category: Nowalk, A.J.]]
+
[[Category: Nowalk AJ]]
-
[[Category: Vaughan, K.G.]]
+
[[Category: Vaughan KG]]
-
[[Category: FE]]
+
-
[[Category: PO4]]
+
-
[[Category: ferric iron binding protein]]
+
-
[[Category: iron transport]]
+
-
[[Category: periplasmic binding protein]]
+
-
[[Category: transferrin superfamily]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb 3 09:53:40 2008''
+

Current revision

FERRIC-BINDING PROTEIN FROM HAEMOPHILUS INFLUENZAE

PDB ID 1mrp

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1mrp"
Personal tools