1o70

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[[Image:1o70.gif|left|200px]]<br /><applet load="1o70" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="1o70, resolution 2.60&Aring;" />
 
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'''NOVEL FOLD REVEALED BY THE STRUCTURE OF A FAS1 DOMAIN PAIR FROM THE INSECT CELL ADHESION MOLECULE FASCICLIN I'''<br />
 
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==Overview==
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==Novel Fold Revealed by the Structure of a FAS1 Domain Pair from the Insect Cell Adhesion Molecule Fasciclin I==
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Fasciclin I is an insect neural cell adhesion molecule consisting of four, FAS1 domains, homologs of which are present in many bacterial, plant, and, animal proteins. The crystal structure of FAS1 domains 3 and 4 of, Drosophila fasciclin I reveals a novel domain fold, consisting of a, seven-stranded beta wedge and a number of alpha helices. The two domains, are arranged in a linear fashion and interact through a substantial polar, interface. Missense mutations in the FAS1 domains of the human protein, betaig-h3 cause corneal dystrophies. Many mutations alter highly conserved, core residues, but the two most common mutations, affecting Arg-124 and, Arg-555, map to exposed alpha-helical regions, suggesting reduced protein, solubility as the disease mechanism.
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<StructureSection load='1o70' size='340' side='right'caption='[[1o70]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[1o70]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O70 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1O70 FirstGlance]. <br>
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1O70 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster] with <scene name='pdbligand=SO4:'>SO4</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Known structural/functional Site: <scene name='pdbsite=AC1:So4+Binding+Site+For+Chain+A'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O70 OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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==Reference==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1o70 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1o70 OCA], [https://pdbe.org/1o70 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1o70 RCSB], [https://www.ebi.ac.uk/pdbsum/1o70 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1o70 ProSAT]</span></td></tr>
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Novel fold revealed by the structure of a FAS1 domain pair from the insect cell adhesion molecule fasciclin I., Clout NJ, Tisi D, Hohenester E, Structure. 2003 Feb;11(2):197-203. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12575939 12575939]
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FAS1_DROME FAS1_DROME] Neural cell adhesion molecule.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/o7/1o70_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1o70 ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Drosophila melanogaster]]
[[Category: Drosophila melanogaster]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Clout, N.J.]]
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[[Category: Clout NJ]]
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[[Category: Hohenester, E.]]
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[[Category: Hohenester E]]
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[[Category: Tisi, D.]]
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[[Category: Tisi D]]
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[[Category: SO4]]
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[[Category: axon guidance]]
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[[Category: cell adhesion]]
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[[Category: corneal dystrophy]]
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[[Category: extracellular module]]
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[[Category: genetic disorder]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb 3 09:54:17 2008''
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Current revision

Novel Fold Revealed by the Structure of a FAS1 Domain Pair from the Insect Cell Adhesion Molecule Fasciclin I

PDB ID 1o70

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