3tkb

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (13:31, 14 March 2024) (edit) (undo)
 
(4 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:3tkb.png|left|200px]]
 
-
<!--
+
==crystal structure of human uracil-DNA glycosylase D183G/K302R mutant==
-
The line below this paragraph, containing "STRUCTURE_3tkb", creates the "Structure Box" on the page.
+
<StructureSection load='3tkb' size='340' side='right'caption='[[3tkb]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[3tkb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TKB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TKB FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene></td></tr>
-
{{STRUCTURE_3tkb| PDB=3tkb | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tkb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tkb OCA], [https://pdbe.org/3tkb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tkb RCSB], [https://www.ebi.ac.uk/pdbsum/3tkb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tkb ProSAT]</span></td></tr>
 +
</table>
 +
== Disease ==
 +
[https://www.uniprot.org/uniprot/UNG_HUMAN UNG_HUMAN] Defects in UNG are a cause of immunodeficiency with hyper-IgM type 5 (HIGM5) [MIM:[https://omim.org/entry/608106 608106]. A rare immunodeficiency syndrome characterized by normal or elevated serum IgM levels with absence of IgG, IgA, and IgE. It results in a profound susceptibility to bacterial infections.<ref>PMID:12958596</ref> <ref>PMID:15967827</ref>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/UNG_HUMAN UNG_HUMAN] Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
-
===crystal structure of human uracil-DNA glycosylase D183G/K302R mutant===
+
==See Also==
-
 
+
*[[DNA glycosylase 3D structures|DNA glycosylase 3D structures]]
-
 
+
== References ==
-
<!--
+
<references/>
-
The line below this paragraph, {{ABSTRACT_PUBMED_21959147}}, adds the Publication Abstract to the page
+
__TOC__
-
(as it appears on PubMed at http://www.pubmed.gov), where 21959147 is the PubMed ID number.
+
</StructureSection>
-
-->
+
-
{{ABSTRACT_PUBMED_21959147}}
+
-
 
+
-
==About this Structure==
+
-
[[3tkb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TKB OCA].
+
-
 
+
-
==Reference==
+
-
<ref group="xtra">PMID:021959147</ref><references group="xtra"/>
+
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Uracil-DNA glycosylase]]
+
[[Category: Large Structures]]
-
[[Category: Assefa, N G.]]
+
[[Category: Assefa NG]]
-
[[Category: Moe, E.]]
+
[[Category: Moe E]]
-
[[Category: Niiranen, L.]]
+
[[Category: Niiranen L]]
-
[[Category: Smalas, A O.]]
+
[[Category: Smalas AO]]
-
[[Category: Willassen, N P.]]
+
[[Category: Willassen NP]]
-
[[Category: Alpha/beta protein]]
+
-
[[Category: Glycosidase]]
+
-
[[Category: Hydrolase]]
+

Current revision

crystal structure of human uracil-DNA glycosylase D183G/K302R mutant

PDB ID 3tkb

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3tkb"
Personal tools