3tsz

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[[Image:3tsz.png|left|200px]]
 
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==crystal structure of PDZ3-SH3-GUK core module from human ZO-1 in complex with 12mer peptide from human JAM-A cytoplasmic tail==
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The line below this paragraph, containing "STRUCTURE_3tsz", creates the "Structure Box" on the page.
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<StructureSection load='3tsz' size='340' side='right'caption='[[3tsz]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3tsz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TSZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TSZ FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.502&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tsz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tsz OCA], [https://pdbe.org/3tsz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tsz RCSB], [https://www.ebi.ac.uk/pdbsum/3tsz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tsz ProSAT]</span></td></tr>
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{{STRUCTURE_3tsz| PDB=3tsz | SCENE= }}
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</table>
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== Function ==
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===crystal structure of PDZ3-SH3-GUK core module from human ZO-1 in complex with 12mer peptide from human JAM-A cytoplasmic tail===
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[https://www.uniprot.org/uniprot/ZO1_HUMAN ZO1_HUMAN] The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions. Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells.<ref>PMID:21240187</ref>
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[3tsz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TSZ OCA].
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Lavie, A.]]
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[[Category: Large Structures]]
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[[Category: Nomme, J.]]
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[[Category: Lavie A]]
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[[Category: Cell adhesion]]
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[[Category: Nomme J]]
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[[Category: Jam]]
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[[Category: Pdz3-sh3-guk]]
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[[Category: Scaffolding]]
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[[Category: Tight junction]]
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Current revision

crystal structure of PDZ3-SH3-GUK core module from human ZO-1 in complex with 12mer peptide from human JAM-A cytoplasmic tail

PDB ID 3tsz

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