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3azd

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[[Image:3azd.png|left|200px]]
 
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==Crystal structure of tropomyosin N-terminal fragment at 0.98A resolution==
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The line below this paragraph, containing "STRUCTURE_3azd", creates the "Structure Box" on the page.
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<StructureSection load='3azd' size='340' side='right'caption='[[3azd]], [[Resolution|resolution]] 0.98&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3azd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] and [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AZD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3AZD FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 0.98&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3azd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3azd OCA], [https://pdbe.org/3azd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3azd RCSB], [https://www.ebi.ac.uk/pdbsum/3azd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3azd ProSAT]</span></td></tr>
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{{STRUCTURE_3azd| PDB=3azd | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GCN4_YEAST GCN4_YEAST] Is a transcription factor that is responsible for the activation of more than 30 genes required for amino acid or for purine biosynthesis in response to amino acid or purine starvation. Binds and recognize the DNA sequence: 5'-TGA[CG]TCA-3'.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Tropomyosin (TM) is an elongated two-chain protein that binds along actin filaments. Important binding sites are localized in the N-terminus of tropomyosin. The structure of the N-terminus of the long muscle alpha-TM has been solved by both NMR and X-ray crystallography. Only the NMR structure of the N-terminus of the short nonmuscle alpha-TM is available. Here, the crystal structure of the N-terminus of the short nonmuscle alpha-TM (alphaTm1bZip) at a resolution of 0.98 A is reported, which was solved from crystals belonging to space group P3(1) with unit-cell parameters a = b = 33.00, c = 52.03 A, alpha = beta = 90, gamma = 120 degrees . The first five N-terminal residues are flexible and residues 6-35 form an alpha-helical coiled coil. The overall fold and the secondary structure of the crystal structure of alphaTM1bZip are highly similar to the NMR structure and the atomic coordinates of the corresponding C(alpha) atoms between the two structures superimpose with a root-mean-square deviation of 0.60 A. The crystal structure validates the NMR structure, with the positions of the side chains being determined precisely in our structure.
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===Crystal structure of tropomyosin N-terminal fragment at 0.98A resolution===
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Structure of a tropomyosin N-terminal fragment at 0.98 A resolution.,Meshcheryakov VA, Krieger I, Kostyukova AS, Samatey FA Acta Crystallogr D Biol Crystallogr. 2011 Sep;67(Pt 9):822-5. Epub 2011, Aug 9. PMID:21904035<ref>PMID:21904035</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3azd" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_21904035}}, adds the Publication Abstract to the page
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*[[Tropomyosin|Tropomyosin]]
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(as it appears on PubMed at http://www.pubmed.gov), where 21904035 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_21904035}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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[[3azd]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AZD OCA].
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[[Category: Rattus norvegicus]]
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[[Category: Saccharomyces cerevisiae S288C]]
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==Reference==
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[[Category: Kostyukova AS]]
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<ref group="xtra">PMID:021904035</ref><references group="xtra"/>
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[[Category: Krieger I]]
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[[Category: Kostyukova, A S.]]
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[[Category: Meshcheryakov VA]]
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[[Category: Krieger, I.]]
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[[Category: Samatey FA]]
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[[Category: Meshcheryakov, V A.]]
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[[Category: Samatey, F A.]]
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[[Category: Actin-binding protein]]
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[[Category: Coiled-coil]]
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[[Category: Muscle protein]]
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Current revision

Crystal structure of tropomyosin N-terminal fragment at 0.98A resolution

PDB ID 3azd

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