2l4z

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[[Image:2l4z.png|left|200px]]
 
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==NMR structure of fusion of CtIP (641-685) to LMO4-LIM1 (18-82)==
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The line below this paragraph, containing "STRUCTURE_2l4z", creates the "Structure Box" on the page.
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<StructureSection load='2l4z' size='340' side='right'caption='[[2l4z]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2l4z]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L4Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L4Z FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_2l4z| PDB=2l4z | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l4z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l4z OCA], [https://pdbe.org/2l4z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l4z RCSB], [https://www.ebi.ac.uk/pdbsum/2l4z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l4z ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/LMO4_MOUSE LMO4_MOUSE] Probable transcriptional factor.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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LIM-only protein 4 (LMO4) is strongly linked to the progression of breast cancer. Although the mechanisms underlying this phenomenon are not well understood, a role is emerging for LMO4 in regulation of the cell cycle. We determined the solution structure of LMO4 in complex with CtIP (C-terminal binding protein interacting protein)/RBBP8, a tumour suppressor protein that is involved in cell cycle progression, DNA repair and transcriptional regulation. Our data reveal that CtIP and the essential LMO cofactor LDB1 (LIM-domain binding protein 1) bind to the same face on LMO4 and cannot simultaneously bind to LMO4. We hypothesise that overexpression of LMO4 may disrupt some of the normal tumour suppressor activities of CtIP, thereby contributing to breast cancer progression.
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===NMR structure of fusion of CtIP (641-685) to LMO4-LIM1 (18-82)===
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Structural Basis of the Interaction of the Breast Cancer Oncogene LMO4 with the Tumour Suppressor CtIP/RBBP8.,Stokes PH, Liew CW, Kwan AH, Foo P, Barker HE, Djamirze A, O'Reilly V, Visvader JE, Mackay JP, Matthews JM J Mol Biol. 2013 Apr 12;425(7):1101-10. doi: 10.1016/j.jmb.2013.01.017. Epub 2013, Jan 23. PMID:23353824<ref>PMID:23353824</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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==About this Structure==
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</div>
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[[2l4z]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens,_undefined Homo sapiens, undefined]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L4Z OCA].
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<div class="pdbe-citations 2l4z" style="background-color:#fffaf0;"></div>
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[[Category: Homo sapiens, undefined]]
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== References ==
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[[Category: Kwan, A H.]]
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<references/>
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[[Category: Liew, C.]]
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__TOC__
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[[Category: Matthews, J M.]]
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</StructureSection>
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[[Category: Stokes, P H.]]
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[[Category: Homo sapiens]]
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[[Category: Hydrolase]]
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[[Category: Large Structures]]
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[[Category: Lim domain]]
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[[Category: Mus musculus]]
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[[Category: Lim-interaction domain]]
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[[Category: Kwan AH]]
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[[Category: Lim-only protein]]
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[[Category: Liew C]]
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[[Category: Lmo4]]
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[[Category: Matthews JM]]
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[[Category: Metal binding protein]]
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[[Category: Stokes PH]]
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[[Category: Protein-protein interaction]]
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[[Category: Rbbp8/ctip]]
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Current revision

NMR structure of fusion of CtIP (641-685) to LMO4-LIM1 (18-82)

PDB ID 2l4z

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