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Pertussis toxin
From Proteopedia
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| - | < | + | <StructureSection load='1prt' size='350' side='right' caption='Pertussis toxin (PDB entry [[1prt]])' scene=''> |
| + | == Function == | ||
| + | '''Pertussis toxin''' (PT) is produced by the bacterium ''Bordetella pertussis'' and is the cause of whooping cough<ref>PMID:15845471</ref>. For additional details see [[Pertussis Toxin-ATP Complex]].<br /> | ||
| + | '''Pertactin''' is another toxin produced by ''Bordetella''. For details see [[P.69 Pertactin Structure and Function]]. | ||
| + | |||
| + | == Relevance == | ||
| + | PT is associated with exacerbated host airway response during whooping cough infection and may inhibit host mechanisms of attenuating inflammation of the airways<ref>PMID:23027529</ref>. | ||
| + | </StructureSection> | ||
| + | == 3D Structures of Pertussis toxin == | ||
| + | |||
| + | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| + | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
| + | |||
| + | *Pertussis toxin | ||
| + | |||
| + | **[[1prt]] – BpPT - ''Bordetella pertussis''<br /> | ||
| + | **[[1pto]] – BpPT + galactose<br /> | ||
| + | **[[1bcp]] – BpPT + ATP<br /> | ||
| + | **[[6ro0]] – BpPT 1,2,5 subunits + islet-activating protein S2 + islet-activating protein S3 + islet-activating protein S4<br /> | ||
| + | **[[7ski]] – BpPT subunit 1 + phenanthridine derivative<br /> | ||
| + | **[[7sky]] – BpPT subunit 1 + NAD<br /> | ||
| + | **[[7u6z]] – BpPT subunit 1 (mutant) + NAD<br /> | ||
| + | **[[7sne]] – BpPT subunit 1 + BaAD<br /> | ||
| + | **[[7skk]] – BpPT subunit 1 + ADPR + nicotinamide<br /> | ||
| + | |||
| + | *Pertussis-like toxin | ||
| + | |||
| + | **[[4z9d]] – EcPLT subunit A (mutant) – ''Escherichia coli''<br /> | ||
| + | **[[4z9c]] – EcPLT subunits A,B <br /> | ||
| + | **[[7k7h]] – SaPLT subunits A,B + antibody – ''Salmonella enterica'' – Cryo EM<br /> | ||
| + | |||
| + | *'''Pertactin''' | ||
| + | |||
| + | **[[1dab]] - BpPer<br /> | ||
| + | **[[2iou]] - Per extracellular domain + major tropism determinant - ''Bordetella bronchiseptica''<br /> | ||
| + | |||
| + | }} | ||
| + | == References == | ||
| + | <references/> | ||
| + | [[Category:Topic Page]] | ||
Current revision
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3D Structures of Pertussis toxin
Updated on 22-August-2023
References
- ↑ Carbonetti NH, Artamonova GV, Andreasen C, Bushar N. Pertussis toxin and adenylate cyclase toxin provide a one-two punch for establishment of Bordetella pertussis infection of the respiratory tract. Infect Immun. 2005 May;73(5):2698-703. PMID:15845471 doi:http://dx.doi.org/10.1128/IAI.73.5.2698-2703.2005
- ↑ Connelly CE, Sun Y, Carbonetti NH. Pertussis toxin exacerbates and prolongs airway inflammatory responses during Bordetella pertussis infection. Infect Immun. 2012 Dec;80(12):4317-32. doi: 10.1128/IAI.00808-12. Epub 2012 Oct, 1. PMID:23027529 doi:http://dx.doi.org/10.1128/IAI.00808-12
