3tc5

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[[Image:3tc5.png|left|200px]]
 
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==Selective targeting of disease-relevant protein binding domains by O-phosphorylated natural product derivatives==
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The line below this paragraph, containing "STRUCTURE_3tc5", creates the "Structure Box" on the page.
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<StructureSection load='3tc5' size='340' side='right'caption='[[3tc5]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3tc5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TC5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TC5 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3T5:(11ALPHA,16ALPHA)-9-FLUORO-11,17-DIHYDROXY-16-METHYL-3,20-DIOXOPREGNA-1,4-DIEN-21-YL+DIHYDROGEN+PHOSPHATE'>3T5</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene></td></tr>
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{{STRUCTURE_3tc5| PDB=3tc5 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tc5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tc5 OCA], [https://pdbe.org/3tc5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tc5 RCSB], [https://www.ebi.ac.uk/pdbsum/3tc5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tc5 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PIN1_HUMAN PIN1_HUMAN] Essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Displays a preference for an acidic residue N-terminal to the isomerized proline bond. Catalyzes pSer/Thr-Pro cis/trans isomerizations. Down-regulates kinase activity of BTK. Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation.<ref>PMID:15664191</ref> <ref>PMID:16644721</ref> <ref>PMID:21497122</ref>
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===Selective targeting of disease-relevant protein binding domains by O-phosphorylated natural product derivatives===
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==See Also==
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*[[Peptidyl-prolyl cis-trans isomerase 3D structures|Peptidyl-prolyl cis-trans isomerase 3D structures]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_21797253}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 21797253 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_21797253}}
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==About this Structure==
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[[3tc5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TC5 OCA].
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==Reference==
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<ref group="xtra">PMID:021797253</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Peptidylprolyl isomerase]]
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[[Category: Large Structures]]
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[[Category: Berg, T.]]
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[[Category: Berg T]]
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[[Category: Elumalai, N.]]
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[[Category: Elumalai N]]
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[[Category: Graeber, M.]]
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[[Category: Graeber M]]
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[[Category: Hausch, F.]]
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[[Category: Hausch F]]
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[[Category: Holak, T A.]]
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[[Category: Holak TA]]
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[[Category: Janczyk, W.]]
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[[Category: Janczyk W]]
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[[Category: Kozany, C.]]
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[[Category: Kozany C]]
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[[Category: Sperl, B.]]
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[[Category: Sperl B]]
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[[Category: Cell cycle]]
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[[Category: Isomerase-isomerase inhibitor complex]]
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[[Category: Nucleus]]
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[[Category: Oncogenic transformation]]
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[[Category: Phosphoprotein]]
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[[Category: Rotamase]]
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[[Category: Small molecule]]
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Current revision

Selective targeting of disease-relevant protein binding domains by O-phosphorylated natural product derivatives

PDB ID 3tc5

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