1oi1

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[[Image:1oi1.jpg|left|200px]]<br /><applet load="1oi1" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="1oi1, resolution 1.78&Aring;" />
 
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'''CRYSTAL STRUCTURE OF THE MBT DOMAINS OF HUMAN SCML2'''<br />
 
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==About this Structure==
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==Crystal Structure of the MBT domains of Human SCML2==
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1OI1 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=PEG:'>PEG</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Known structural/functional Site: <scene name='pdbsite=AC1:Peg+Binding+Site+For+Chain+A'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OI1 OCA].
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<StructureSection load='1oi1' size='340' side='right'caption='[[1oi1]], [[Resolution|resolution]] 1.78&Aring;' scene=''>
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[[Category: Homo sapiens]]
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== Structural highlights ==
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[[Category: Single protein]]
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<table><tr><td colspan='2'>[[1oi1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OI1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OI1 FirstGlance]. <br>
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[[Category: Allen, M.D.]]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.78&#8491;</td></tr>
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[[Category: Bycroft, M.]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
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[[Category: Murzin, A.G.]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1oi1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oi1 OCA], [https://pdbe.org/1oi1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1oi1 RCSB], [https://www.ebi.ac.uk/pdbsum/1oi1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1oi1 ProSAT]</span></td></tr>
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[[Category: Sathyamurthy, A.]]
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</table>
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[[Category: PEG]]
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== Function ==
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[[Category: crystal structure]]
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[https://www.uniprot.org/uniprot/SCML2_HUMAN SCML2_HUMAN] Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development (By similarity).
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[[Category: mbt]]
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== Evolutionary Conservation ==
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[[Category: scml2]]
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oi/1oi1_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1oi1 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Sex Comb on Midleg (SCM) belongs to the Polycomb group of proteins, which are involved in transcriptional regulation in Drosophila. It is one of the components of Polycomb repressive complex 1, a multiprotein complex of Polycomb group proteins involved in the maintenance of repression and the blocking of chromatin remodeling. SCM contains two approximately 100-residue malignant brain tumor (MBT) repeats at the N terminus. These repeats are also found in other proteins involved in transcriptional repression. Here, we report the 1.78-A crystal structure of the two MBT repeats of SCM-like 2 (SCML2), a human homologue of SCM. Each repeat consists of an extended arm and a beta-barrel core. There are significant structural similarities to the Tudor, PWWP, and chromo domains, suggesting probable evolutionary relationships and functional similarities between the MBT repeats and these domains.
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb 3 09:58:22 2008''
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Crystal structure of the malignant brain tumor (MBT) repeats in Sex Comb on Midleg-like 2 (SCML2).,Sathyamurthy A, Allen MD, Murzin AG, Bycroft M J Biol Chem. 2003 Nov 21;278(47):46968-73. Epub 2003 Sep 1. PMID:12952983<ref>PMID:12952983</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1oi1" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Allen MD]]
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[[Category: Bycroft M]]
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[[Category: Murzin AG]]
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[[Category: Sathyamurthy A]]

Current revision

Crystal Structure of the MBT domains of Human SCML2

PDB ID 1oi1

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