2q24

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[[Image:2q24.png|left|200px]]
 
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==Crystal structure of TetR transcriptional regulator SCO0520 from Streptomyces coelicolor==
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The line below this paragraph, containing "STRUCTURE_2q24", creates the "Structure Box" on the page.
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<StructureSection load='2q24' size='340' side='right'caption='[[2q24]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2q24]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_coelicolor_A3(2) Streptomyces coelicolor A3(2)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q24 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Q24 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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{{STRUCTURE_2q24| PDB=2q24 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2q24 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q24 OCA], [https://pdbe.org/2q24 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2q24 RCSB], [https://www.ebi.ac.uk/pdbsum/2q24 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2q24 ProSAT], [https://www.topsan.org/Proteins/MCSG/2q24 TOPSAN]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q9RJL5_STRCO Q9RJL5_STRCO]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q2/2q24_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2q24 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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A structure of the apo-form of the putative transcriptional regulator SCO0520 from Streptomyces coelicolor A3(2) was determined at 1.8 A resolution. SCO0520 belongs to the TetR family of regulators. In the crystal lattice, the asymmetric unit contains two monomers that form an ohm-shaped dimer. The distance between the two DNA-recognition domains is much longer than the corresponding distances in the known structures of other TetR family proteins. In addition, the subunits in the dimer have different conformational states, resulting in different relative positions of the DNA-binding and regulatory domains. Similar conformational modifications are observed in other TetR regulators and result from ligand binding. These studies provide information about the flexibility of SCO0520 molecule and its putative biological function.
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===Crystal structure of TetR transcriptional regulator SCO0520 from Streptomyces coelicolor===
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Crystal structure of a putative transcriptional regulator SCO0520 from Streptomyces coelicolor A3(2) reveals an unusual dimer among TetR family proteins.,Filippova EV, Chruszcz M, Cymborowski M, Gu J, Savchenko A, Edwards A, Minor W J Struct Funct Genomics. 2011 May 29. PMID:21625866<ref>PMID:21625866</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2q24" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 21625866 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_21625866}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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[[2q24]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacteria Bacteria]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q24 OCA].
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[[Category: Chruszcz M]]
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[[Category: Cymborowski M]]
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==Reference==
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[[Category: Edwards AM]]
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<ref group="xtra">PMID:021625866</ref><references group="xtra"/>
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[[Category: Filippova EV]]
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[[Category: Bacteria]]
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[[Category: Gu J]]
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[[Category: Chruszcz, M.]]
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[[Category: Joachimiak A]]
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[[Category: Cymborowski, M.]]
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[[Category: Koclega KD]]
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[[Category: Edwards, A M.]]
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[[Category: Minor W]]
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[[Category: Filippova, E V.]]
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[[Category: Savchenko A]]
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[[Category: Gu, J.]]
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[[Category: Xu X]]
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[[Category: Joachimiak, A.]]
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[[Category: Koclega, K D.]]
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[[Category: MCSG, Midwest Center for Structural Genomics.]]
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[[Category: Minor, W.]]
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[[Category: Savchenko, A.]]
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[[Category: Xu, X.]]
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[[Category: Mcsg]]
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[[Category: Midwest center for structural genomic]]
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[[Category: Protein structure initiative]]
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[[Category: Psi]]
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[[Category: Structural genomic]]
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[[Category: Transcription]]
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[[Category: Transcriptional regulator]]
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Current revision

Crystal structure of TetR transcriptional regulator SCO0520 from Streptomyces coelicolor

PDB ID 2q24

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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