2lc0

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[[Image:2lc0.jpg|left|200px]]
 
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==Rv0020c_Nter structure==
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The line below this paragraph, containing "STRUCTURE_2lc0", creates the "Structure Box" on the page.
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<StructureSection load='2lc0' size='340' side='right'caption='[[2lc0]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2lc0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LC0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LC0 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lc0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lc0 OCA], [https://pdbe.org/2lc0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lc0 RCSB], [https://www.ebi.ac.uk/pdbsum/2lc0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lc0 ProSAT]</span></td></tr>
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{{STRUCTURE_2lc0| PDB=2lc0 | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FHAA_MYCTU FHAA_MYCTU] Regulates cell growth and peptidoglycan synthesis by binding to MviN. May inhibit the late stages of peptidoglycan synthesis.<ref>PMID:22275220</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The protein Rv0020c from Mycobacterium tuberculosis, also called FhaA, is one of the major substrates of the essential Ser/Thr protein kinase (STPK) PknB. The protein is composed of three domains and is phosphorylated on a unique site in its N terminus. We solved the solution structure of both N- and C-terminal domains and demonstrated that the approximately 300 amino acids of the intermediate domain are not folded. We present evidence that the FHA, a phosphospecific binding domain, of Rv0020c does not interact with the phosphorylated catalytic domains of PknB, but with the phosphorylated juxtamembrane domain that links the catalytic domain to the mycobacterial membrane. We also demonstrated that the degree and the pattern of phosphorylation of this juxtamembrane domain modulates the affinity of the substrate (Rv0020c) toward its kinase (PknB).
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===Rv0020c_Nter structure===
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Structural Insight into the Mycobacterium tuberculosis Rv0020c Protein and Its Interaction with the PknB Kinase.,Roumestand C, Leiba J, Galophe N, Margeat E, Padilla A, Bessin Y, Barthe P, Molle V, Cohen-Gonsaud M Structure. 2011 Oct 12;19(10):1525-34. PMID:22000520<ref>PMID:22000520</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_22000520}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2lc0" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 22000520 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_22000520}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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[[2lc0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LC0 OCA].
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[[Category: Mycobacterium tuberculosis H37Rv]]
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[[Category: Barthe PP]]
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==Reference==
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[[Category: Cohen-Gonsaud MM]]
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<ref group="xtra">PMID:022000520</ref><references group="xtra"/>
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[[Category: Roumestand C]]
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[[Category: Mycobacterium tuberculosis]]
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[[Category: Barthe, P P.]]
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[[Category: Cohen-Gonsaud, M M.]]
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[[Category: Roumestand, C.]]
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[[Category: Fhaa]]
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[[Category: Kinase substrate]]
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[[Category: Protein binding]]
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Current revision

Rv0020c_Nter structure

PDB ID 2lc0

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