3t6p

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[[Image:3t6p.jpg|left|200px]]
 
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==IAP antagonist-induced conformational change in cIAP1 promotes E3 ligase activation via dimerization==
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The line below this paragraph, containing "STRUCTURE_3t6p", creates the "Structure Box" on the page.
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<StructureSection load='3t6p' size='340' side='right'caption='[[3t6p]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3t6p]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T6P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3T6P FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.897&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_3t6p| PDB=3t6p | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3t6p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3t6p OCA], [https://pdbe.org/3t6p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3t6p RCSB], [https://www.ebi.ac.uk/pdbsum/3t6p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3t6p ProSAT]</span></td></tr>
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</table>
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===IAP antagonist-induced conformational change in cIAP1 promotes E3 ligase activation via dimerization===
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== Function ==
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[https://www.uniprot.org/uniprot/BIRC2_HUMAN BIRC2_HUMAN] Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling, and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, TRAF2, DIABLO/SMAC, MAP3K14/NIK, MAP3K5/ASK1, IKBKG/NEMO and MXD1/MAD1. Can also function as an E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. Can stimulate the transcriptional activity of E2F1. Plays a role in the modulation of the cell cycle.<ref>PMID:15665297</ref> <ref>PMID:18082613</ref> <ref>PMID:21145488</ref> <ref>PMID:21653699</ref> <ref>PMID:21931591</ref>
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_22021857}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 22021857 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_22021857}}
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==About this Structure==
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[[3t6p]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T6P OCA].
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==Reference==
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<ref group="xtra">PMID:022021857</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Deshayes, K.]]
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[[Category: Large Structures]]
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[[Category: Dueber, E C.]]
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[[Category: Deshayes K]]
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[[Category: Elliott, M.]]
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[[Category: Dueber EC]]
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[[Category: Fairbrother, W J.]]
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[[Category: Elliott M]]
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[[Category: Fedorova, A V.]]
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[[Category: Fairbrother WJ]]
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[[Category: Giannetti, A M.]]
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[[Category: Fedorova AV]]
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[[Category: Hymowitz, S.]]
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[[Category: Giannetti AM]]
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[[Category: Lingel, A.]]
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[[Category: Hymowitz S]]
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[[Category: Maurer, B.]]
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[[Category: Lingel A]]
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[[Category: Schoeffler, A J.]]
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[[Category: Maurer B]]
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[[Category: Varfolomeev, E.]]
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[[Category: Schoeffler AJ]]
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[[Category: Vucic, D.]]
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[[Category: Varfolomeev E]]
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[[Category: Wallweber, H.]]
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[[Category: Vucic D]]
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[[Category: Wu, P.]]
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[[Category: Wallweber H]]
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[[Category: Zobel, K.]]
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[[Category: Wu P]]
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[[Category: Apoptosis]]
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[[Category: Zobel K]]
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[[Category: Bir]]
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[[Category: Card]]
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[[Category: Caspase]]
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[[Category: E3]]
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[[Category: Iap family]]
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[[Category: Ring]]
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[[Category: Smac mimetic]]
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[[Category: Smac/diablo]]
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[[Category: Uba]]
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[[Category: Ubiquitin]]
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[[Category: Ubiquitin ligase]]
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Current revision

IAP antagonist-induced conformational change in cIAP1 promotes E3 ligase activation via dimerization

PDB ID 3t6p

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