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3au3

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[[Image:3au3.jpg|left|200px]]
 
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==Crystal structure of armadillo repeat domain of APC==
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The line below this paragraph, containing "STRUCTURE_3au3", creates the "Structure Box" on the page.
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<StructureSection load='3au3' size='340' side='right'caption='[[3au3]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3au3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AU3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3AU3 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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{{STRUCTURE_3au3| PDB=3au3 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3au3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3au3 OCA], [https://pdbe.org/3au3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3au3 RCSB], [https://www.ebi.ac.uk/pdbsum/3au3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3au3 ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Adenomatous polyposis coli (APC) is a tumor suppressor protein commonly mutated in colorectal tumors. APC plays important roles in Wnt signaling and other cellular processes. Here, we present the crystal structure of the armadillo repeat (Arm) domain of APC, which facilitates the binding of APC to various proteins. APC-Arm forms a superhelix with a positively charged groove. We also determined the structure of the complex of APC-Arm with the tyrosine-rich (YY) domain of the Src-associated in mitosis, 68 kDa protein (Sam68), which regulates TCF-1 alternative splicing. Sam68-YY forms numerous interactions with the residues on the groove and is thereby fixed in a bent conformation. We assessed the effects of mutations and phosphorylation on complex formation between APC-Arm and Sam68-YY. Structural comparisons revealed different modes of ligand recognition between the Arm domains of APC and other Arm-containing proteins.
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===Crystal structure of armadillo repeat domain of APC===
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Crystal structures of the armadillo repeat domain of adenomatous polyposis coli and its complex with the tyrosine-rich domain of sam68.,Morishita EC, Murayama K, Kato-Murayama M, Ishizuka-Katsura Y, Tomabechi Y, Hayashi T, Terada T, Handa N, Shirouzu M, Akiyama T, Yokoyama S Structure. 2011 Oct 12;19(10):1496-508. PMID:22000517<ref>PMID:22000517</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3au3" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_22000517}}, adds the Publication Abstract to the page
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*[[Adenomatous polyposis coli|Adenomatous polyposis coli]]
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(as it appears on PubMed at http://www.pubmed.gov), where 22000517 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_22000517}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[3au3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AU3 OCA].
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==Reference==
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<ref group="xtra">PMID:022000517</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Kato-Murayama, M.]]
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[[Category: Large Structures]]
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[[Category: Murayama, K.]]
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[[Category: Kato-Murayama M]]
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[[Category: Shirouzu, M.]]
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[[Category: Murayama K]]
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[[Category: Terada, T.]]
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[[Category: Shirouzu M]]
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[[Category: Yokoyama, S.]]
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[[Category: Terada T]]
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[[Category: Armadillo repeat]]
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[[Category: Yokoyama S]]
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[[Category: National project on protein structural and functional analyse]]
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[[Category: Nppsfa]]
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[[Category: Riken structural genomics/proteomics initiative]]
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[[Category: Rsgi]]
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[[Category: Signal transduction]]
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[[Category: Signaling protein]]
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[[Category: Structural genomic]]
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Current revision

Crystal structure of armadillo repeat domain of APC

PDB ID 3au3

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