3s8k

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[[Image:3s8k.jpg|left|200px]]
 
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==Crystal structure of a papaya latex serine protease inhibitor (PPI) at 1.7A resolution==
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The line below this paragraph, containing "STRUCTURE_3s8k", creates the "Structure Box" on the page.
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<StructureSection load='3s8k' size='340' side='right'caption='[[3s8k]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3s8k]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Carica_papaya Carica papaya]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S8K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3S8K FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NH4:AMMONIUM+ION'>NH4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_3s8k| PDB=3s8k | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3s8k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3s8k OCA], [https://pdbe.org/3s8k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3s8k RCSB], [https://www.ebi.ac.uk/pdbsum/3s8k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3s8k ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/LSPI_CARPA LSPI_CARPA]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Proteases carry out a number of crucial functions inside and outside the cell. To protect the cells against the potentially lethal activities of these enzymes, specific inhibitors are produced to tightly regulate the protease activity. Independent reports suggest that the Kunitz-soybean trypsin inhibitor (STI) family has the potential to inhibit proteases with different specificities. In this study, we use a combination of biophysical methods to define the structural basis of the interaction of papaya protease inhibitor (PPI) with serine proteases. We show that PPI is a multiple-headed inhibitor; a single PPI molecule can bind two trypsin units at the same time. Based on sequence and structural analysis, we hypothesize that the inherent plasticity of the beta-trefoil fold is paramount in the functional evolution of this family toward multiple protease inhibition.
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===Crystal structure of a papaya latex serine protease inhibitor (PPI) at 1.7A resolution===
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The plasticity of the beta-trefoil fold constitutes an evolutionary platform for protease inhibition.,Azarkan M, Martinez-Rodriguez S, Buts L, Baeyens-Volant D, Garcia-Pino A J Biol Chem. 2011 Dec 23;286(51):43726-34. Epub 2011 Oct 25. PMID:22027836<ref>PMID:22027836</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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==About this Structure==
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</div>
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[[3s8k]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Carica_papaya Carica papaya]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S8K OCA].
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<div class="pdbe-citations 3s8k" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Carica papaya]]
[[Category: Carica papaya]]
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[[Category: Garcia-Pino, A.]]
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[[Category: Large Structures]]
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[[Category: Hydrolase inhibitor]]
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[[Category: Garcia-Pino A]]
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[[Category: Kunitz-sti fold]]
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[[Category: Protease inhibitor]]
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Current revision

Crystal structure of a papaya latex serine protease inhibitor (PPI) at 1.7A resolution

PDB ID 3s8k

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