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3sfm

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[[Image:3sfm.jpg|left|200px]]
 
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==Novel crystallization conditions for tandem variant R67 DHFR yields wild-type crystal structure==
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The line below this paragraph, containing "STRUCTURE_3sfm", creates the "Structure Box" on the page.
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<StructureSection load='3sfm' size='340' side='right'caption='[[3sfm]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3sfm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SFM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SFM FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene></td></tr>
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{{STRUCTURE_3sfm| PDB=3sfm | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3sfm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sfm OCA], [https://pdbe.org/3sfm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3sfm RCSB], [https://www.ebi.ac.uk/pdbsum/3sfm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3sfm ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DYR21_ECOLX DYR21_ECOLX] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
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===Novel crystallization conditions for tandem variant R67 DHFR yields wild-type crystal structure===
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==See Also==
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*[[Dihydrofolate reductase 3D structures|Dihydrofolate reductase 3D structures]]
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__TOC__
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==About this Structure==
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</StructureSection>
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[[3sfm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SFM OCA].
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[[Category: Dihydrofolate reductase]]
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[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Berghuis, A M.]]
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[[Category: Large Structures]]
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[[Category: Yachnin, B J.]]
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[[Category: Berghuis AM]]
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[[Category: Antibiotic resistance]]
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[[Category: Yachnin BJ]]
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[[Category: Dhf and nadph-binding]]
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[[Category: Dihydrofolate reductase]]
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[[Category: In situ proteolysis]]
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[[Category: Oxidoreductase]]
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[[Category: Reductase]]
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[[Category: Sh3]]
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[[Category: Type ii dhfr]]
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Current revision

Novel crystallization conditions for tandem variant R67 DHFR yields wild-type crystal structure

PDB ID 3sfm

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