3tht

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[[Image:3tht.jpg|left|200px]]
 
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==Crystal structure and RNA binding properties of the RRM/AlkB domains in human ABH8, an enzyme catalyzing tRNA hypermodification, Northeast Structural Genomics Consortium Target HR5601B==
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The line below this paragraph, containing "STRUCTURE_3tht", creates the "Structure Box" on the page.
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<StructureSection load='3tht' size='340' side='right'caption='[[3tht]], [[Resolution|resolution]] 3.01&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3tht]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3THT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3THT FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.01&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AKG:2-OXOGLUTARIC+ACID'>AKG</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_3tht| PDB=3tht | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tht FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tht OCA], [https://pdbe.org/3tht PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tht RCSB], [https://www.ebi.ac.uk/pdbsum/3tht PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tht ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ALKB8_HUMAN ALKB8_HUMAN] Catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA. Catalyzes the last step in the formation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA. Has a preference for tRNA(Arg) and tRNA(Glu), and does not bind tRNA(Lys). Required for normal survival after DNA damage. May inhibit apoptosis and promote cell survival and angiogenesis.<ref>PMID:19293182</ref> <ref>PMID:20308323</ref>
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===Crystal structure and RNA binding properties of the RRM/AlkB domains in human ABH8, an enzyme catalyzing tRNA hypermodification, Northeast Structural Genomics Consortium Target HR5601B===
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==See Also==
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*[[Dioxygenase 3D structures|Dioxygenase 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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[[3tht]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3THT OCA].
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Forouhar, F.]]
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[[Category: Large Structures]]
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[[Category: Hunt, J F.]]
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[[Category: Forouhar F]]
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[[Category: Levy, M.]]
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[[Category: Hunt JF]]
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[[Category: NESG, Northeast Structural Genomics Consortium.]]
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[[Category: Levy M]]
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[[Category: Pastore, C.]]
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[[Category: Pastore C]]
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[[Category: Topalidou, I.]]
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[[Category: Topalidou I]]
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[[Category: Yan, A C.]]
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[[Category: Yan AC]]
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[[Category: Alpha-beta two domain protein containing a zinc structure motif]]
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[[Category: Nesg]]
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[[Category: Northeast structural genomics consortium]]
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[[Category: Oxidoreductase]]
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[[Category: Psi-biology]]
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[[Category: Structural genomic]]
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[[Category: Trna modifying enzyme]]
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Current revision

Crystal structure and RNA binding properties of the RRM/AlkB domains in human ABH8, an enzyme catalyzing tRNA hypermodification, Northeast Structural Genomics Consortium Target HR5601B

PDB ID 3tht

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