3tq6

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[[Image:3tq6.jpg|left|200px]]
 
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==Crystal structure of human mitochondrial transcription factor A, TFAM or mtTFA, bound to the light strand promoter LSP==
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The line below this paragraph, containing "STRUCTURE_3tq6", creates the "Structure Box" on the page.
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<StructureSection load='3tq6' size='340' side='right'caption='[[3tq6]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3tq6]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TQ6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TQ6 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.45&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=BRU:5-BROMO-2-DEOXYURIDINE-5-MONOPHOSPHATE'>BRU</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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{{STRUCTURE_3tq6| PDB=3tq6 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tq6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tq6 OCA], [https://pdbe.org/3tq6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tq6 RCSB], [https://www.ebi.ac.uk/pdbsum/3tq6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tq6 ProSAT]</span></td></tr>
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</table>
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===Crystal structure of human mitochondrial transcription factor A, TFAM or mtTFA, bound to the light strand promoter LSP===
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== Function ==
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[https://www.uniprot.org/uniprot/TFAM_HUMAN TFAM_HUMAN] Binds to the mitochondrial light strand promoter and functions in mitochondrial transcription regulation. Required for accurate and efficient promoter recognition by the mitochondrial RNA polymerase. Promotes transcription initiation from the HSP1 and the light strand promoter by binding immediately upstream of transcriptional start sites. Is able to unwind DNA. Bends the mitochondrial light strand promoter DNA into a U-turn shape via its HMG boxes. Required for maintenance of normal levels of mitochondrial DNA. May play a role in organizing and compacting mitochondrial DNA.<ref>PMID:1737790</ref> <ref>PMID:20410300</ref> <ref>PMID:19304746</ref> <ref>PMID:22037172</ref> <ref>PMID:22037171</ref>
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== References ==
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==About this Structure==
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<references/>
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[[3tq6]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TQ6 OCA].
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Bernado, P.]]
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[[Category: Large Structures]]
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[[Category: Coll, M.]]
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[[Category: Bernado P]]
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[[Category: Fernandez-Millan, P.]]
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[[Category: Coll M]]
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[[Category: Jacobs, H T.]]
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[[Category: Fernandez-Millan P]]
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[[Category: Jimenez-Menendez, N.]]
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[[Category: Jacobs HT]]
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[[Category: Montoya, J.]]
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[[Category: Jimenez-Menendez N]]
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[[Category: Rubio-Cosials, A.]]
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[[Category: Montoya J]]
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[[Category: Sola, M.]]
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[[Category: Rubio-Cosials A]]
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[[Category: Sydow, J F.]]
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[[Category: Sola M]]
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[[Category: Dna-binding]]
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[[Category: Sydow JF]]
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[[Category: Hmgb-ubf_hmg-box]]
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[[Category: Light-strand mitochondrial promoter]]
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[[Category: Lsp]]
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[[Category: Minor groove]]
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[[Category: Mitochondrial nucleoid]]
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[[Category: Mitochondrion]]
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[[Category: Tandem hmg box]]
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[[Category: Transcription]]
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[[Category: Transcription regulation]]
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[[Category: Transcription-dna complex]]
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Current revision

Crystal structure of human mitochondrial transcription factor A, TFAM or mtTFA, bound to the light strand promoter LSP

PDB ID 3tq6

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