3tq8

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[[Image:3tq8.jpg|left|200px]]
 
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==Structure of the dihydrofolate reductase (folA) from Coxiella burnetii in complex with trimethoprim==
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The line below this paragraph, containing "STRUCTURE_3tq8", creates the "Structure Box" on the page.
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<StructureSection load='3tq8' size='340' side='right'caption='[[3tq8]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3tq8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Coxiella_burnetii Coxiella burnetii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TQ8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TQ8 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=TOP:TRIMETHOPRIM'>TOP</scene></td></tr>
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{{STRUCTURE_3tq8| PDB=3tq8 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tq8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tq8 OCA], [https://pdbe.org/3tq8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tq8 RCSB], [https://www.ebi.ac.uk/pdbsum/3tq8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tq8 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q83AB2_COXBU Q83AB2_COXBU] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.[PIRNR:PIRNR000194]
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===Structure of the dihydrofolate reductase (folA) from Coxiella burnetii in complex with trimethoprim===
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==See Also==
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*[[Dihydrofolate reductase 3D structures|Dihydrofolate reductase 3D structures]]
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__TOC__
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==About this Structure==
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</StructureSection>
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[[3tq8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Coxiella_burnetii Coxiella burnetii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TQ8 OCA].
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[[Category: Coxiella burnetii]]
[[Category: Coxiella burnetii]]
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[[Category: Dihydrofolate reductase]]
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[[Category: Large Structures]]
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[[Category: Cassidy, M.]]
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[[Category: Cassidy M]]
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[[Category: Franklin, M C.]]
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[[Category: Franklin MC]]
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[[Category: Hillerich, B.]]
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[[Category: Hillerich B]]
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[[Category: Love, J.]]
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[[Category: Love J]]
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[[Category: Dihydrofolate reductase]]
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[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
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Current revision

Structure of the dihydrofolate reductase (folA) from Coxiella burnetii in complex with trimethoprim

PDB ID 3tq8

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