1szj

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:35, 14 February 2024) (edit) (undo)
 
(16 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1szj.gif|left|200px]]<br /><applet load="1szj" size="350" color="white" frame="true" align="right" spinBox="true"
 
-
caption="1szj, resolution 2.0&Aring;" />
 
-
'''STRUCTURE OF HOLO-GLYCERALDEHYDE-3-PHOSPHATE-DEHYDROGENASE FROM PALINURUS VERSICOLOR REFINED 2.0 ANGSTROM RESOLUTION'''<br />
 
-
==Overview==
+
==STRUCTURE OF HOLO-GLYCERALDEHYDE-3-PHOSPHATE-DEHYDROGENASE FROM PALINURUS VERSICOLOR REFINED 2.0 ANGSTROM RESOLUTION==
-
When the active-site carboxymethylated D-glyceraldehyde-3-phosphate, dehydrogenase is irradiated with ultraviolet light in the presence of, NAD+, a fluorescent NAD derivative that is covalently linked to the enzyme, is obtained. A preliminary crystallographic study of this fluorescent, derivative, as well as of the native and the carboxymethylated enzymes, from Palinurus versicolor, showed that they are isomorphous and belong to, space group C2 as reported for the native enzyme from Palinurus vulgaris., The three forms of the enzyme, although they have identical unit cell, parameters, differ considerably in their diffraction patterns, indicating, marked differences in conformation in spite of the fact that they differ, chemically only in a restricted region around the active site.
+
<StructureSection load='1szj' size='340' side='right'caption='[[1szj]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[1szj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Panulirus_versicolor Panulirus versicolor]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SZJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SZJ FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1szj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1szj OCA], [https://pdbe.org/1szj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1szj RCSB], [https://www.ebi.ac.uk/pdbsum/1szj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1szj ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/G3P_PANVR G3P_PANVR]
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sz/1szj_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1szj ConSurf].
 +
<div style="clear:both"></div>
-
==About this Structure==
+
==See Also==
-
1SZJ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Palinurus_versicolor Palinurus versicolor] with <scene name='pdbligand=SO4:'>SO4</scene> and <scene name='pdbligand=NAD:'>NAD</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Glyceraldehyde-3-phosphate_dehydrogenase_(phosphorylating) Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.12 1.2.1.12] Known structural/functional Site: <scene name='pdbsite=ACT:Active+Site+Residues+CYS+149+And+HIS+176'>ACT</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SZJ OCA].
+
*[[Aldehyde dehydrogenase 3D structures|Aldehyde dehydrogenase 3D structures]]
-
 
+
*[[Glyceraldehyde-3-phosphate dehydrogenase 3D structures|Glyceraldehyde-3-phosphate dehydrogenase 3D structures]]
-
==Reference==
+
__TOC__
-
Preliminary crystallographic studies of lobster D-glyceraldehyde-3-phosphate dehydrogenase and the modified enzyme carrying the fluorescent derivative., Song SY, Gao YG, Zhou JM, Tsou CL, J Mol Biol. 1983 Dec 5;171(2):225-8. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=6655693 6655693]
+
</StructureSection>
-
[[Category: Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)]]
+
[[Category: Large Structures]]
-
[[Category: Palinurus versicolor]]
+
[[Category: Panulirus versicolor]]
-
[[Category: Single protein]]
+
[[Category: Li J]]
-
[[Category: Li, J.]]
+
[[Category: Lin Z]]
-
[[Category: Lin, Z.]]
+
[[Category: Song S]]
-
[[Category: Song, S.]]
+
-
[[Category: NAD]]
+
-
[[Category: SO4]]
+
-
[[Category: allosterism]]
+
-
[[Category: d-glyceraldehyde-3-phosphate-dehydrogenase]]
+
-
[[Category: molecular symmetry]]
+
-
[[Category: oxidoreductase]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb 3 10:02:18 2008''
+

Current revision

STRUCTURE OF HOLO-GLYCERALDEHYDE-3-PHOSPHATE-DEHYDROGENASE FROM PALINURUS VERSICOLOR REFINED 2.0 ANGSTROM RESOLUTION

PDB ID 1szj

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1szj"
Personal tools