3u50

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'''Unreleased structure'''
 
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The entry 3u50 is ON HOLD until Paper Publication
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==Crystal Structure of the Tetrahymena telomerase processivity factor Teb1 OB-C==
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<StructureSection load='3u50' size='340' side='right'caption='[[3u50]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3u50]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Tetrahymena_thermophila Tetrahymena thermophila]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U50 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3U50 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3u50 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u50 OCA], [https://pdbe.org/3u50 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3u50 RCSB], [https://www.ebi.ac.uk/pdbsum/3u50 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3u50 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TEB1_TETTS TEB1_TETTS] Single-stranded DNA (ssDNA)-binding protein that mediates the recruitment of telomerase to telomeric DNA (PubMed:19941821, PubMed:20363756, PubMed:25225329, PubMed:22143754). Telomerase is an essential ribonucleoprotein (RNP) enzyme that copies new telomeric repeats onto chromosome ends by repetitively synthesizing the short telomere-repeat sequence 5'-TTGGGG-3' using an RNA template component TER (PubMed:19941821). Acts as part of a replication protein A (RPA)-related subcomplex of the holoenzyme telomerase ribonucleoprotein complex: TEB1 specifically recognizes and binds telomeric ssDNA, thereby mediating the recruitment of the holoenzyme telomerase RNP complex to telomeres (PubMed:19941821, PubMed:25225329, PubMed:27895115). TEB1 is related to RPA1 subunit of the RPA complex but is specific to telomeric DNA, which is not the case of RPA1 (PubMed:25225329).<ref>PMID:19941821</ref> <ref>PMID:20363756</ref> <ref>PMID:22143754</ref> <ref>PMID:25225329</ref> <ref>PMID:27895115</ref>
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Authors: Zeng, Z., Huang, J., Yang, Y., Lei, M.
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==See Also==
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*[[Telomerase-associated protein|Telomerase-associated protein]]
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Description: Crystal Structure of the Tetrahymena telomerase processivity factor Teb1 OB-C
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Tetrahymena thermophila]]
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[[Category: Huang J]]
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[[Category: Lei M]]
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[[Category: Yang Y]]
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[[Category: Zeng Z]]

Current revision

Crystal Structure of the Tetrahymena telomerase processivity factor Teb1 OB-C

PDB ID 3u50

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