3ue8
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Kynurenine Aminotransferase II Inhibitors== | |
| - | + | <StructureSection load='3ue8' size='340' side='right'caption='[[3ue8]], [[Resolution|resolution]] 3.22Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3ue8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UE8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UE8 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.22Å</td></tr> | |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=09M:(5-HYDROXY-4-{[(1-HYDROXY-2-OXO-1,2-DIHYDROQUINOLIN-3-YL)AMINO]METHYL}-6-METHYLPYRIDIN-3-YL)METHYL+DIHYDROGEN+PHOSPHATE'>09M</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ue8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ue8 OCA], [https://pdbe.org/3ue8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ue8 RCSB], [https://www.ebi.ac.uk/pdbsum/3ue8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ue8 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/AADAT_HUMAN AADAT_HUMAN] Transaminase with broad substrate specificity. Has transaminase activity towards aminoadipate, kynurenine, methionine and glutamate. Shows activity also towards tryptophan, aspartate and hydroxykynurenine. Accepts a variety of oxo-acids as amino-group acceptors, with a preference for 2-oxoglutarate, 2-oxocaproic acid, phenylpyruvate and alpha-oxo-gamma-methiol butyric acid. Can also use glyoxylate as amino-group acceptor (in vitro).<ref>PMID:18620547</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Anderson M]] | ||
| + | [[Category: Bechle BM]] | ||
| + | [[Category: Campbell BM]] | ||
| + | [[Category: Claffey MM]] | ||
| + | [[Category: Dounay AB]] | ||
| + | [[Category: Edelweiss E]] | ||
| + | [[Category: Evdokimov A]] | ||
| + | [[Category: Fonseca KR]] | ||
| + | [[Category: Gan X]] | ||
| + | [[Category: Ghosh S]] | ||
| + | [[Category: Hayward MM]] | ||
| + | [[Category: Horner W]] | ||
| + | [[Category: Kim JY]] | ||
| + | [[Category: McAllister LA]] | ||
| + | [[Category: Pandit J]] | ||
| + | [[Category: Paradis V]] | ||
| + | [[Category: Parikh VD]] | ||
| + | [[Category: Reese MR]] | ||
| + | [[Category: Rong SB]] | ||
| + | [[Category: Salafia MA]] | ||
| + | [[Category: Schuyten K]] | ||
| + | [[Category: Strick CA]] | ||
| + | [[Category: Tuttle JB]] | ||
| + | [[Category: Valentine J]] | ||
| + | [[Category: Verhoest PR]] | ||
| + | [[Category: Wang H]] | ||
| + | [[Category: Zawadzke LE]] | ||
Current revision
Kynurenine Aminotransferase II Inhibitors
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Categories: Homo sapiens | Large Structures | Anderson M | Bechle BM | Campbell BM | Claffey MM | Dounay AB | Edelweiss E | Evdokimov A | Fonseca KR | Gan X | Ghosh S | Hayward MM | Horner W | Kim JY | McAllister LA | Pandit J | Paradis V | Parikh VD | Reese MR | Rong SB | Salafia MA | Schuyten K | Strick CA | Tuttle JB | Valentine J | Verhoest PR | Wang H | Zawadzke LE
