1upr
From Proteopedia
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| - | [[Image:1upr.jpg|left|200px]]<br /><applet load="1upr" size="350" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="1upr, resolution 2.27Å" /> | ||
| - | '''CRYSTAL STRUCTURE OF THE PEPP1 PLECKSTRIN HOMOLOGY DOMAIN IN COMPLEX WITH INOSITOL 1,3,4,5-TETRAKISPHOSPHATE'''<br /> | ||
| - | == | + | ==Crystal structure of the PEPP1 pleckstrin homology domain in complex with Inositol 1,3,4,5-tetrakisphosphate== |
| - | + | <StructureSection load='1upr' size='340' side='right'caption='[[1upr]], [[Resolution|resolution]] 2.27Å' scene=''> | |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[1upr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UPR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UPR FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.27Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4IP:INOSITOL-(1,3,4,5)-TETRAKISPHOSPHATE'>4IP</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1upr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1upr OCA], [https://pdbe.org/1upr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1upr RCSB], [https://www.ebi.ac.uk/pdbsum/1upr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1upr ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PKHA4_HUMAN PKHA4_HUMAN] Binds specifically to phosphatidylinositol 3-phosphate (PtdIns3P), but not to other phosphoinositides.<ref>PMID:11001876</ref> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/up/1upr_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1upr ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | + | [[Category: Alessi DR]] | |
| - | [[Category: Alessi | + | [[Category: Deak M]] |
| - | [[Category: Deak | + | [[Category: Komander D]] |
| - | [[Category: Komander | + | [[Category: Milburn CC]] |
| - | [[Category: Milburn | + | [[Category: Van Aalten DMF]] |
| - | [[Category: | + | |
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Current revision
Crystal structure of the PEPP1 pleckstrin homology domain in complex with Inositol 1,3,4,5-tetrakisphosphate
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