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3toa

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[[Image:3toa.jpg|left|200px]]
 
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==Human MOF crystal structure with active site lysine partially acetylated==
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The line below this paragraph, containing "STRUCTURE_3toa", creates the "Structure Box" on the page.
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<StructureSection load='3toa' size='340' side='right'caption='[[3toa]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3toa]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TOA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TOA FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.004&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_3toa| PDB=3toa | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3toa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3toa OCA], [https://pdbe.org/3toa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3toa RCSB], [https://www.ebi.ac.uk/pdbsum/3toa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3toa ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/KAT8_HUMAN KAT8_HUMAN] Histone acetyltransferase which may be involved in transcriptional activation. May influence the function of ATM. As part of the MSL complex it is involved in acetylation of nucleosomal histone H4 producing specifically H4K16ac. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. That activity is less specific than the one of the MSL complex.<ref>PMID:12397079</ref> <ref>PMID:15923642</ref> <ref>PMID:20018852</ref>
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===Human MOF crystal structure with active site lysine partially acetylated===
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==See Also==
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*[[Histone acetyltransferase 3D structures|Histone acetyltransferase 3D structures]]
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== References ==
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 22020126 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_22020126}}
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==About this Structure==
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[[3toa]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TOA OCA].
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==Reference==
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<ref group="xtra">PMID:022020126</ref><references group="xtra"/>
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[[Category: Histone acetyltransferase]]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Ding, E C.]]
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[[Category: Large Structures]]
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[[Category: Marmorstein, R.]]
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[[Category: Ding EC]]
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[[Category: Yuan, H.]]
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[[Category: Marmorstein R]]
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[[Category: Hat domain]]
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[[Category: Yuan H]]
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[[Category: Myst protein]]
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[[Category: Transferase]]
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[[Category: Zinc finger]]
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Current revision

Human MOF crystal structure with active site lysine partially acetylated

PDB ID 3toa

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