3ris

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[[Image:3ris.jpg|left|200px]]
 
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==Crystal structure of the catalytic domain of UCHL5, a proteasome-associated human deubiquitinating enzyme, reveals an unproductive form of the enzyme==
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The line below this paragraph, containing "STRUCTURE_3ris", creates the "Structure Box" on the page.
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<StructureSection load='3ris' size='340' side='right'caption='[[3ris]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3ris]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RIS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RIS FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.398&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_3ris| PDB=3ris | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ris FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ris OCA], [https://pdbe.org/3ris PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ris RCSB], [https://www.ebi.ac.uk/pdbsum/3ris PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ris ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/UCHL5_HUMAN UCHL5_HUMAN] Protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome. Putative regulatory component of the INO80 complex; however is inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome via ADRM1.<ref>PMID:16906146</ref> <ref>PMID:18922472</ref>
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===Crystal structure of the catalytic domain of UCHL5, a proteasome-associated human deubiquitinating enzyme, reveals an unproductive form of the enzyme===
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==See Also==
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*[[Thioesterase 3D structures|Thioesterase 3D structures]]
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== References ==
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<references/>
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 21995438 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_21995438}}
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==About this Structure==
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[[3ris]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RIS OCA].
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==Reference==
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<ref group="xtra">PMID:021995438</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Ubiquitinyl hydrolase 1]]
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[[Category: Large Structures]]
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[[Category: Das, C.]]
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[[Category: Das C]]
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[[Category: Maiti, T K.]]
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[[Category: Maiti TK]]
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[[Category: Permaul, M.]]
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[[Category: Permaul M]]
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[[Category: Alpha-beta-alpha fold]]
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[[Category: Cysteine protease]]
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[[Category: Deubiquitinating enzyme]]
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[[Category: Hydrolase]]
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[[Category: Thiol hydrolase]]
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[[Category: Ubiquitin hydrolase]]
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Current revision

Crystal structure of the catalytic domain of UCHL5, a proteasome-associated human deubiquitinating enzyme, reveals an unproductive form of the enzyme

PDB ID 3ris

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