2yjn

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[[Image:2yjn.jpg|left|200px]]
 
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==Structure of the glycosyltransferase EryCIII from the erythromycin biosynthetic pathway, in complex with its activating partner, EryCII==
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The line below this paragraph, containing "STRUCTURE_2yjn", creates the "Structure Box" on the page.
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<StructureSection load='2yjn' size='340' side='right'caption='[[2yjn]], [[Resolution|resolution]] 3.09&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2yjn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharopolyspora_erythraea_NRRL_2338 Saccharopolyspora erythraea NRRL 2338]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YJN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YJN FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.091&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yjn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yjn OCA], [https://pdbe.org/2yjn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yjn RCSB], [https://www.ebi.ac.uk/pdbsum/2yjn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yjn ProSAT]</span></td></tr>
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{{STRUCTURE_2yjn| PDB=2yjn | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ERYC3_SACEN ERYC3_SACEN] Catalyzes the conversion of alpha-L-mycarosylerythronolide B into erythromycin D in the erythromycin biosynthesis pathway.<ref>PMID:15303858</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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In the biosynthesis of the clinically important antibiotic erythromycin D, the glycosyltransferase (GT) EryCIII, in concert with its partner EryCII, attaches a nucleotide-activated sugar to the macrolide scaffold with high specificity. To understand the role of EryCII, we have determined the crystal structure of the EryCIII.EryCII complex at 3.1 A resolution. The structure reveals a heterotetramer with a distinctive, elongated quaternary organization. The EryCIII subunits form an extensive self-complementary dimer interface at the center of the complex, and the EryCII subunits lie on the periphery. EryCII binds in the vicinity of the putative macrolide binding site of EryCIII but does not make direct interactions with this site. Our biophysical and enzymatic data support a model in which EryCII stabilizes EryCIII and also functions as an allosteric activator of the GT.
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===STRUCTURE OF THE GLYCOSYLTRANSFERASE ERYCIII FROM THE ERYTHROMYCIN BIOSYNTHETIC PATHWAY, IN COMPLEX WITH ITS ACTIVATING PARTNER, ERYCII===
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Structure of the Glycosyltransferase EryCIII in Complex with its Activating P450 Homologue EryCII.,Moncrieffe MC, Fernandez MJ, Spiteller D, Matsumura H, Gay NJ, Luisi BF, Leadlay PF J Mol Biol. 2012 Jan 6;415(1):92-101. Epub 2011 Oct 25. PMID:22056329<ref>PMID:22056329</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2yjn" style="background-color:#fffaf0;"></div>
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==About this Structure==
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==See Also==
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[[2yjn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharopolyspora_erythraea Saccharopolyspora erythraea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YJN OCA].
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*[[Glycosyltransferase 3D structures|Glycosyltransferase 3D structures]]
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[[Category: Saccharopolyspora erythraea]]
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== References ==
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[[Category: Fernandez, M J.]]
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<references/>
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[[Category: Gay, N J.]]
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__TOC__
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[[Category: Leadlay, P F.]]
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</StructureSection>
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[[Category: Luisi, B F.]]
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[[Category: Large Structures]]
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[[Category: Matsumura, H.]]
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[[Category: Saccharopolyspora erythraea NRRL 2338]]
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[[Category: Moncrieffe, M C.]]
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[[Category: Fernandez MJ]]
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[[Category: Spiteller, D.]]
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[[Category: Gay NJ]]
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[[Category: Cytochrome p450]]
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[[Category: Leadlay PF]]
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[[Category: Transferase]]
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[[Category: Luisi BF]]
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[[Category: Matsumura H]]
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[[Category: Moncrieffe MC]]
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[[Category: Spiteller D]]

Current revision

Structure of the glycosyltransferase EryCIII from the erythromycin biosynthetic pathway, in complex with its activating partner, EryCII

PDB ID 2yjn

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