3sqd

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[[Image:3sqd.jpg|left|200px]]
 
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==Crystal structure of human PTIP BRCT5/6-gamma H2AX complex==
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The line below this paragraph, containing "STRUCTURE_3sqd", creates the "Structure Box" on the page.
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<StructureSection load='3sqd' size='340' side='right'caption='[[3sqd]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3sqd]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SQD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SQD FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.153&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
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{{STRUCTURE_3sqd| PDB=3sqd | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3sqd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sqd OCA], [https://pdbe.org/3sqd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3sqd RCSB], [https://www.ebi.ac.uk/pdbsum/3sqd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3sqd ProSAT]</span></td></tr>
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</table>
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===Crystal structure of human PTIP BRCT5/6-gamma H2AX complex===
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== Function ==
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[https://www.uniprot.org/uniprot/PAXI1_HUMAN PAXI1_HUMAN] Involved in DNA damage response and in transcriptional regulation through histone methyltransferase (HMT) complexes. Plays a role in early development. In DNA damage response is required for cell survival after ionizing radiation. In vitro shown to be involved in the homologous recombination mechanism for the repair of double-strand breaks (DSBs). Its localization to DNA damage foci requires RNF8 and UBE2N. Recruits TP53BP1 to DNA damage foci and, at least in particular repair processes, effective DNA damage response appears to require the association with TP53BP1 phosphorylated by ATM at 'Ser-25'. Together with TP53BP1 regulates ATM association. Recruits PAGR1 to sites of DNA damage and the PAGR1:PAXIP1 complex is required for cell survival in response to DNA damage; the function is probbaly independent of MLL-containing histone methyltransferase (HMT) complexes. Promotes ubiquitination of PCNA following UV irradiation and may regulate recruitment of polymerase eta and RAD51 to chromatin after DNA damage. Proposed to be involved in transcriptional regulation by linking MLL-containing histone methyltransferase (HMT) complexes to gene promoters by interacting with promoter-bound transcription factors such as PAX2. Associates with gene promoters that are known to be regulated by KMT2D/MLL2. During immunoglobulin class switching in activated B-cells is involved in trimethylation of histone H3 at 'Lys-4' and in transcription initiation of downstream switch regions at the immunoglobulin heavy-chain (Igh) locus; this function appears to involve the recruitment of MLL-containing HMT complexes.<ref>PMID:14576432</ref> <ref>PMID:15456759</ref> <ref>PMID:17690115</ref> <ref>PMID:17925232</ref> <ref>PMID:18353733</ref> <ref>PMID:20088963</ref>
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== References ==
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==About this Structure==
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<references/>
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[[3sqd]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SQD OCA].
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Shao, Z H.]]
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[[Category: Large Structures]]
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[[Category: Yan, W.]]
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[[Category: Shao ZH]]
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[[Category: Cell cycle]]
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[[Category: Yan W]]
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[[Category: H2ax]]
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[[Category: Tandem brct domain]]
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Current revision

Crystal structure of human PTIP BRCT5/6-gamma H2AX complex

PDB ID 3sqd

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