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3nz7

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[[Image:3nz7.png|left|200px]]
 
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==A bimolecular anti-parallel-stranded Oxytricha nova telomeric quadruplex in complex with a 3,6-disubstituted acridine ligand containing bis-3-fluoropyrrolidine end side chains==
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The line below this paragraph, containing "STRUCTURE_3nz7", creates the "Structure Box" on the page.
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<StructureSection load='3nz7' size='340' side='right'caption='[[3nz7]], [[Resolution|resolution]] 1.10&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3nz7]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NZ7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NZ7 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=SNS:3,6-BIS(3-(3-(S)-FLUOROPYRROLINDINO)PROPIONAMIDO)ACRIDINE'>SNS</scene></td></tr>
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{{STRUCTURE_3nz7| PDB=3nz7 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3nz7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nz7 OCA], [https://pdbe.org/3nz7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3nz7 RCSB], [https://www.ebi.ac.uk/pdbsum/3nz7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3nz7 ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Comparative X-ray structure studies reveal that C-F bond incorporation into the peripheral pyrrolidine moieties of the G-quadruplex DNA binding ligand BSU6039 leads to a distinct pyrrolidine ring conformation, relative to the non-fluorinated analogue, and with a different binding mode involving reversal of the pyrrolidinium N(+)-H orientation.
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===A bimolecular anti-parallel-stranded Oxytricha nova telomeric quadruplex in complex with a 3,6-disubstituted acridine ligand containing bis-3-fluoropyrrolidine end side chains===
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Fluorine in medicinal chemistry: beta-fluorination of peripheral pyrrolidines attached to acridine ligands affects their interactions with G-quadruplex DNA.,Campbell NH, Smith DL, Reszka AP, Neidle S, O'Hagan D Org Biomol Chem. 2011 Mar 7;9(5):1328-31. Epub 2011 Jan 10. PMID:21221451<ref>PMID:21221451</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_21221451}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 3nz7" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 21221451 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_21221451}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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[[3nz7]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NZ7 OCA].
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[[Category: Campbell NH]]
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[[Category: Neidle S]]
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==Reference==
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<ref group="xtra">PMID:021221451</ref><references group="xtra"/>
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[[Category: Campbell, N H.]]
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[[Category: Neidle, S.]]
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[[Category: Acridine]]
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[[Category: Anti-parallel]]
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[[Category: Bimolecular]]
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[[Category: Bsu-6039]]
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[[Category: Bsu6039]]
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[[Category: Dna]]
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[[Category: Fluorination]]
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[[Category: G-quadruplex]]
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[[Category: Macromolecule]]
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[[Category: Oxtyricha nova]]
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[[Category: Quadruplex]]
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[[Category: Telomere]]
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Current revision

A bimolecular anti-parallel-stranded Oxytricha nova telomeric quadruplex in complex with a 3,6-disubstituted acridine ligand containing bis-3-fluoropyrrolidine end side chains

PDB ID 3nz7

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