1ktc

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[[Image:1ktc.png|left|200px]]
 
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==The Structure of alpha-N-Acetylgalactosaminidase==
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The line below this paragraph, containing "STRUCTURE_1ktc", creates the "Structure Box" on the page.
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<StructureSection load='1ktc' size='340' side='right'caption='[[1ktc]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1ktc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KTC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KTC FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NGA:N-ACETYL-D-GALACTOSAMINE'>NGA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_1ktc| PDB=1ktc | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ktc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ktc OCA], [https://pdbe.org/1ktc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ktc RCSB], [https://www.ebi.ac.uk/pdbsum/1ktc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ktc ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NAGAB_CHICK NAGAB_CHICK] Removes terminal alpha-N-acetylgalactosamine residues from glycolipids and glycopeptides. Required for the breakdown of glycolipids.[UniProtKB:P17050]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kt/1ktc_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ktc ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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In the lysosome, glycosidases degrade glycolipids, glycoproteins, and oligosaccharides. Mutations in glycosidases cause disorders characterized by the deposition of undegraded carbohydrates. Schindler and Fabry diseases are caused by the incomplete degradation of carbohydrates with terminal alpha-N-acetylgalactosamine and alpha-galactose, respectively. Here we present the X-ray structure of alpha-N-acetylgalactosaminidase (alpha-NAGAL), the glycosidase that removes alpha-N-acetylgalactosamine, and the structure with bound ligand. The active site residues of alpha-NAGAL are conserved in the closely related enzyme a-galactosidase A (alpha-GAL). The structure demonstrates the catalytic mechanisms of both enzymes and reveals the structural basis of mutations causing Schindler and Fabry diseases. As alpha-NAGAL and alpha-GAL produce type O "universal donor" blood from type A and type B blood, the alpha-NAGAL structure will aid in the engineering of improved enzymes for blood conversion.
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===The Structure of alpha-N-Acetylgalactosaminidase===
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The 1.9 A structure of alpha-N-acetylgalactosaminidase: molecular basis of glycosidase deficiency diseases.,Garman SC, Hannick L, Zhu A, Garboczi DN Structure. 2002 Mar;10(3):425-34. PMID:12005440<ref>PMID:12005440</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_12005440}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1ktc" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 12005440 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_12005440}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[1ktc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KTC OCA].
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==Reference==
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<ref group="xtra">PMID:012005440</ref><references group="xtra"/>
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[[Category: Alpha-N-acetylgalactosaminidase]]
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[[Category: Gallus gallus]]
[[Category: Gallus gallus]]
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[[Category: Garboczi, D N.]]
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[[Category: Large Structures]]
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[[Category: Garman, S C.]]
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[[Category: Garboczi DN]]
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[[Category: Hannick, L.]]
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[[Category: Garman SC]]
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[[Category: Zhu, A.]]
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[[Category: Hannick L]]
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[[Category: Glycoprotein]]
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[[Category: Zhu A]]
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[[Category: Hydrolase]]
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[[Category: Protein-ligand complex]]
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Current revision

The Structure of alpha-N-Acetylgalactosaminidase

PDB ID 1ktc

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