2ydp

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[[Image:2ydp.png|left|200px]]
 
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==Structure of the E242A mutant of the alpha-l-arabinofuranosidase arb93a from fusarium graminearum in complex with an iminosugar inhibitor==
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The line below this paragraph, containing "STRUCTURE_2ydp", creates the "Structure Box" on the page.
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<StructureSection load='2ydp' size='340' side='right'caption='[[2ydp]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2ydp]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Fusarium_graminearum Fusarium graminearum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YDP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YDP FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AHR:ALPHA-L-ARABINOFURANOSE'>AHR</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EDG:1,4-DIDEOXY-1,4-IMINO-L-ARABINITOL'>EDG</scene></td></tr>
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{{STRUCTURE_2ydp| PDB=2ydp | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ydp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ydp OCA], [https://pdbe.org/2ydp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ydp RCSB], [https://www.ebi.ac.uk/pdbsum/2ydp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ydp ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/B8ZY56_GIBZA B8ZY56_GIBZA]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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As part of continued efforts to understand the mechanisms of 1,5-alpha-l-arabinanases better, some arabinan-like iminosugar oligosaccharides were synthesized. An iminosugar analogue of arabinobiose was found to be a good inhibitor of the arabinanase Arb93A from Fusarium graminearum. Structures were determined for complexes of this inhibitor with wild-type Arb93A and a catalytically inactive mutant.
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===STRUCTURE OF THE E242A MUTANT OF THE ALPHA-L-ARABINOFURANOSIDASE ARB93A FROM FUSARIUM GRAMINEARUM IN COMPLEX WITH AN IMINOSUGAR INHIBITOR===
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alpha-L-Arabinofuranosylated pyrrolidines as arabinanase inhibitors.,Goddard-Borger ED, Carapito R, Jeltsch JM, Phalip V, Stick RV, Varrot A Chem Commun (Camb). 2011 Sep 14;47(34):9684-6. Epub 2011 Jul 20. PMID:21773614<ref>PMID:21773614</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2ydp" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 21773614 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_21773614}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Fusarium graminearum]]
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[[2ydp]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Gibberella_zeae Gibberella zeae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YDP OCA].
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[[Category: Large Structures]]
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[[Category: Carapito R]]
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==Reference==
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[[Category: Goddard-Borger ED]]
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<ref group="xtra">PMID:021773614</ref><references group="xtra"/>
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[[Category: Jeltsch JM]]
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[[Category: Alpha-N-arabinofuranosidase]]
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[[Category: Phalip V]]
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[[Category: Gibberella zeae]]
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[[Category: Stick RV]]
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[[Category: Carapito, R.]]
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[[Category: Varrot A]]
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[[Category: Goddard-Borger, E D.]]
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[[Category: Jeltsch, J M.]]
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[[Category: Phalip, V.]]
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[[Category: Stick, R V.]]
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[[Category: Varrot, A.]]
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[[Category: Glycosyl hydrolase]]
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[[Category: Hydrolase]]
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Current revision

Structure of the E242A mutant of the alpha-l-arabinofuranosidase arb93a from fusarium graminearum in complex with an iminosugar inhibitor

PDB ID 2ydp

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