2lke

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[[Image:2lke.png|left|200px]]
 
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==Structures and Interaction Analyses of the Integrin Alpha-M Beta-2 Cytoplasmic Tails==
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The line below this paragraph, containing "STRUCTURE_2lke", creates the "Structure Box" on the page.
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<StructureSection load='2lke' size='340' side='right'caption='[[2lke]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2lke]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LKE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LKE FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lke FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lke OCA], [https://pdbe.org/2lke PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lke RCSB], [https://www.ebi.ac.uk/pdbsum/2lke PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lke ProSAT]</span></td></tr>
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{{STRUCTURE_2lke| PDB=2lke | SCENE= }}
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/ITAM_HUMAN ITAM_HUMAN] Genetic variations in ITGAM has been associated with susceptibility to systemic lupus erythematosus type 6 (SLEB6) [MIM:[https://omim.org/entry/609939 609939]. Systemic lupus erythematosus (SLE) is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system.
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== Function ==
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[https://www.uniprot.org/uniprot/ITAM_HUMAN ITAM_HUMAN] Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain.
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===Structures and Interaction Analyses of the Integrin Alpha-M Beta-2 Cytoplasmic Tails===
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==See Also==
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*[[Integrin 3D structures|Integrin 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_22052909}}, adds the Publication Abstract to the page
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[[Category: Homo sapiens]]
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(as it appears on PubMed at http://www.pubmed.gov), where 22052909 is the PubMed ID number.
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[[Category: Large Structures]]
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[[Category: Amalraj M]]
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{{ABSTRACT_PUBMED_22052909}}
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[[Category: Bhattacharjya S]]
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[[Category: Chua GL]]
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==About this Structure==
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[[Category: Tan SM]]
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[[2lke]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LKE OCA].
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[[Category: Tang XY]]
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==Reference==
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<ref group="xtra">PMID:022052909</ref><references group="xtra"/>
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[[Category: Amalraj, M.]]
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[[Category: Bhattacharjya, S.]]
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[[Category: Chua, G L.]]
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[[Category: Tan, S M.]]
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[[Category: Tang, X Y.]]
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[[Category: Cell adhesion]]
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[[Category: Dpc micelle]]
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[[Category: Myristoylated]]
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Current revision

Structures and Interaction Analyses of the Integrin Alpha-M Beta-2 Cytoplasmic Tails

PDB ID 2lke

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