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2h8p

From Proteopedia

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[[Image:2h8p.png|left|200px]]
 
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==Structure of a K channel with an amide to ester substitution in the selectivity filter==
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The line below this paragraph, containing "STRUCTURE_2h8p", creates the "Structure Box" on the page.
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<StructureSection load='2h8p' size='340' side='right'caption='[[2h8p]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2h8p]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Streptomyces_lividans Streptomyces lividans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H8P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2H8P FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=B3H:(2S)-2-(BUTYRYLOXY)-3-HYDROXYPROPYL+NONANOATE'>B3H</scene>, <scene name='pdbligand=GOA:GLYCOLIC+ACID'>GOA</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
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{{STRUCTURE_2h8p| PDB=2h8p | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2h8p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2h8p OCA], [https://pdbe.org/2h8p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2h8p RCSB], [https://www.ebi.ac.uk/pdbsum/2h8p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2h8p ProSAT]</span></td></tr>
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</table>
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===Structure of a K channel with an amide to ester substitution in the selectivity filter===
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== Function ==
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[https://www.uniprot.org/uniprot/Q569B4_RAT Q569B4_RAT]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 16939283 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h8/2h8p_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_16939283}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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[[2h8p]] is a 4 chain structure of [[Monoclonal Antibody]] and [[Potassium Channel]] with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H8P OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2h8p ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Monoclonal Antibody]]
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*[[Antibody 3D structures|Antibody 3D structures]]
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*[[Potassium Channel]]
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*[[Potassium channel 3D structures|Potassium channel 3D structures]]
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*[[3D structures of non-human antibody|3D structures of non-human antibody]]
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==Reference==
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__TOC__
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<ref group="xtra">PMID:016939283</ref><references group="xtra"/>
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: MacKinnon, R.]]
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[[Category: Streptomyces lividans]]
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[[Category: Muir, T W.]]
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[[Category: MacKinnon R]]
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[[Category: Valiyaveetil, F I.]]
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[[Category: Muir TW]]
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[[Category: Channel]]
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[[Category: Valiyaveetil FI]]
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[[Category: Ester]]
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[[Category: Membrane protein]]
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[[Category: Semi-synthetic]]
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Current revision

Structure of a K channel with an amide to ester substitution in the selectivity filter

PDB ID 2h8p

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