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1nep

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[[Image:1nep.png|left|200px]]
 
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==Crystal Structure Analysis of the Bovine NPC2 (Niemann-Pick C2) Protein==
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The line below this paragraph, containing "STRUCTURE_1nep", creates the "Structure Box" on the page.
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<StructureSection load='1nep' size='340' side='right'caption='[[1nep]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1nep]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NEP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NEP FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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{{STRUCTURE_1nep| PDB=1nep | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nep FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nep OCA], [https://pdbe.org/1nep PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nep RCSB], [https://www.ebi.ac.uk/pdbsum/1nep PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nep ProSAT]</span></td></tr>
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</table>
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===Crystal Structure Analysis of the Bovine NPC2 (Niemann-Pick C2) Protein===
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== Function ==
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[https://www.uniprot.org/uniprot/NPC2_BOVIN NPC2_BOVIN] Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment. Both NPC1 and NPC2 function as the cellular 'tag team duo' (TTD) to catalyze the mobilization of cholesterol within the multivesicular environment of the late endosome (LE) to effect egress through the limiting bilayer of the LE. NPC2 binds unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes and transfers it to the cholesterol-binding pocket of the N-terminal domain of NPC1. Cholesterol binds to NPC1 with the hydroxyl group buried in the binding pocket and is exported from the limiting membrane of late endosomes/ lysosomes to the ER and plasma membrane by an unknown mechanism. The secreted form of NCP2 regulates biliary cholesterol secretion via stimulation of ABCG5/ABCG8-mediated cholesterol transport.<ref>PMID:18823126</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_12591954}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 12591954 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ne/1nep_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_12591954}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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[[1nep]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NEP OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1nep ConSurf].
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<div style="clear:both"></div>
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==Reference==
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== References ==
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<ref group="xtra">PMID:012591954</ref><references group="xtra"/>
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<references/>
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__TOC__
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</StructureSection>
[[Category: Bos taurus]]
[[Category: Bos taurus]]
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[[Category: Friedland, N.]]
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[[Category: Large Structures]]
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[[Category: Liou, H L.]]
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[[Category: Friedland N]]
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[[Category: Lobel, P.]]
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[[Category: Liou H-L]]
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[[Category: Stock, A M.]]
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[[Category: Lobel P]]
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[[Category: Bnpc2]]
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[[Category: Stock AM]]
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[[Category: Cholesterol]]
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[[Category: Ldl]]
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[[Category: Lipid binding protein]]
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[[Category: Niemann-pick c2]]
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[[Category: Npc2]]
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Current revision

Crystal Structure Analysis of the Bovine NPC2 (Niemann-Pick C2) Protein

PDB ID 1nep

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