3n3u

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[[Image:3n3u.png|left|200px]]
 
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==Crystal Structure of IbpAFic2==
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The line below this paragraph, containing "STRUCTURE_3n3u", creates the "Structure Box" on the page.
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<StructureSection load='3n3u' size='340' side='right'caption='[[3n3u]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3n3u]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Histophilus_somni_2336 Histophilus somni 2336]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N3U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3N3U FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.846&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_3n3u| PDB=3n3u | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3n3u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n3u OCA], [https://pdbe.org/3n3u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3n3u RCSB], [https://www.ebi.ac.uk/pdbsum/3n3u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3n3u ProSAT]</span></td></tr>
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</table>
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===Crystal Structure of IbpAFic2===
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== Function ==
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[https://www.uniprot.org/uniprot/IBPA_HISS2 IBPA_HISS2] Adenylyltransferase involved in virulence by mediating the addition of adenosine 5'-monophosphate (AMP) to specific tyrosine residue of host Rho GTPases RhoA, Rac and Cdc42. The resulting AMPylation inactivates Rho GTPases, thereby inhibiting actin assembly in infected cells. Probably also acts as a cysteine protease, which may play a central role after invasion of host cell and in virulence. Possible member (with IbpB) of a 2 partner secretion. Probably able to bind bovine epithelial cells (host cells). May participate in the formation of fibrils at the surface of the bacteria.<ref>PMID:12631474</ref> <ref>PMID:19362538</ref> <ref>PMID:20622875</ref> <ref>PMID:9317034</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 20622875 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/n3/3n3u_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_20622875}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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[[3n3u]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Histophilus_somni Histophilus somni]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N3U OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3n3u ConSurf].
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<div style="clear:both"></div>
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==Reference==
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== References ==
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<ref group="xtra">PMID:020622875</ref><references group="xtra"/>
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<references/>
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[[Category: Histophilus somni]]
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__TOC__
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[[Category: Nicotinamide-nucleotide adenylyltransferase]]
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</StructureSection>
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[[Category: Xiao, J.]]
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[[Category: Histophilus somni 2336]]
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[[Category: Fic domain]]
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[[Category: Large Structures]]
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[[Category: Transferase]]
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[[Category: Xiao J]]

Current revision

Crystal Structure of IbpAFic2

PDB ID 3n3u

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