1914

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[[Image:1914.png|left|200px]]
 
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==SIGNAL RECOGNITION PARTICLE ALU RNA BINDING HETERODIMER, SRP9/14==
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The line below this paragraph, containing "STRUCTURE_1914", creates the "Structure Box" on the page.
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<StructureSection load='1914' size='340' side='right'caption='[[1914]], [[Resolution|resolution]] 2.53&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1914]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1914 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1914 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.53&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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{{STRUCTURE_1914| PDB=1914 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1914 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1914 OCA], [https://pdbe.org/1914 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1914 RCSB], [https://www.ebi.ac.uk/pdbsum/1914 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1914 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SRP14_MOUSE SRP14_MOUSE] Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The mammalian signal recognition particle (SRP) is an 11S cytoplasmic ribonucleoprotein that plays an essential role in protein sorting. SRP recognizes the signal sequence of the nascent polypeptide chain emerging from the ribosome, and targets the ribosome-nascent chain-SRP complex to the rough endoplasmic reticulum. The SRP consists of six polypeptides (SRP9, SRP14, SRP19, SRP54, SRP68 and SRP72) and a single 300 nucleotide RNA molecule. SRP9 and SRP14 proteins form a heterodimer that binds to the Alu domain of SRP RNA which is responsible for translation arrest. We report the first crystal structure of a mammalian SRP protein, that of the mouse SRP9/14 heterodimer, determined at 2.5 A resolution. SRP9 and SRP14 are found to be structurally homologous, containing the same alpha-beta-beta-beta-alpha fold. This we designate the Alu binding module (Alu bm), an additional member of the family of small alpha/beta RNA binding domains. The heterodimer has pseudo 2-fold symmetry and is saddle like, comprising a strongly curved six-stranded amphipathic beta-sheet with the four helices packed on the convex side and the exposed concave surface being lined with positively charged residues.
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===SIGNAL RECOGNITION PARTICLE ALU RNA BINDING HETERODIMER, SRP9/14===
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The crystal structure of the signal recognition particle Alu RNA binding heterodimer, SRP9/14.,Birse DE, Kapp U, Strub K, Cusack S, Aberg A EMBO J. 1997 Jul 1;16(13):3757-66. PMID:9233785<ref>PMID:9233785</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 1914" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 9233785 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9233785}}
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==About this Structure==
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[[1914]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1914 OCA].
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==See Also==
==See Also==
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*[[Nobel Prizes for 3D Molecular Structure]]
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*[[Signal recognition particle 3D structures|Signal recognition particle 3D structures]]
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*[[Treatments:Dipeptidyl Peptidase-4 Inhibitor Pharmacokinetics]]
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== References ==
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*[[User:Wayne Decatur/Interactions between Antibiotics and the Ribosome]]
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<references/>
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:009233785</ref><ref group="xtra">PMID:015215468</ref><references group="xtra"/>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Aberg, A.]]
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[[Category: Aberg A]]
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[[Category: Birse, D.]]
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[[Category: Birse D]]
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[[Category: Cusack, S.]]
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[[Category: Cusack S]]
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[[Category: Kapp, U.]]
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[[Category: Kapp U]]
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[[Category: Strub, K.]]
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[[Category: Strub K]]
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[[Category: Alu domain]]
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[[Category: Rna binding]]
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[[Category: Translation regulation]]
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Current revision

SIGNAL RECOGNITION PARTICLE ALU RNA BINDING HETERODIMER, SRP9/14

PDB ID 1914

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