3vh2

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[[Image:3vh2.png|left|200px]]
 
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==Crystal structure of Saccharomyces cerevisiae Atg7 (1-613)==
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The line below this paragraph, containing "STRUCTURE_3vh2", creates the "Structure Box" on the page.
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<StructureSection load='3vh2' size='340' side='right'caption='[[3vh2]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3vh2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VH2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VH2 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_3vh2| PDB=3vh2 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vh2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vh2 OCA], [https://pdbe.org/3vh2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vh2 RCSB], [https://www.ebi.ac.uk/pdbsum/3vh2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vh2 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ATG7_YEAST ATG7_YEAST] E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 and ATG8 for its conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes.<ref>PMID:9759731</ref> <ref>PMID:8224160</ref> <ref>PMID:7593182</ref> <ref>PMID:10233148</ref> <ref>PMID:10233150</ref> <ref>PMID:11100732</ref> <ref>PMID:11149920</ref> <ref>PMID:12965207</ref> <ref>PMID:15277523</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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E1 enzymes activate ubiquitin-like proteins and transfer them to cognate E2 enzymes. Atg7, a noncanonical E1, activates two ubiquitin-like proteins, Atg8 and Atg12, and plays a crucial role in autophagy. Here, we report crystal structures of full-length Atg7 and its C-terminal domain bound to Atg8 and MgATP, as well as a solution structure of Atg8 bound to the extreme C-terminal domain (ECTD) of Atg7. The unique N-terminal domain (NTD) of Atg7 is responsible for Atg3 (E2) binding, whereas its C-terminal domain is comprised of a homodimeric adenylation domain (AD) and ECTD. The structural and biochemical data demonstrate that Atg8 is initially recognized by the C-terminal tail of ECTD and is then transferred to an AD, where the Atg8 C terminus is attacked by the catalytic cysteine to form a thioester bond. Atg8 is then transferred via a trans mechanism to the Atg3 bound to the NTD of the opposite protomer within a dimer.
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===Crystal structure of Saccharomyces cerevisiae Atg7 (1-613)===
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Structural basis of Atg8 activation by a homodimeric E1, Atg7.,Noda NN, Satoo K, Fujioka Y, Kumeta H, Ogura K, Nakatogawa H, Ohsumi Y, Inagaki F Mol Cell. 2011 Nov 4;44(3):462-75. PMID:22055191<ref>PMID:22055191</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3vh2" style="background-color:#fffaf0;"></div>
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==About this Structure==
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==See Also==
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[[3vh2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VH2 OCA].
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*[[Autophagy-related protein 3D structures|Autophagy-related protein 3D structures]]
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[[Category: Saccharomyces cerevisiae]]
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== References ==
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[[Category: Inagaki, F.]]
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<references/>
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[[Category: Noda, N N.]]
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__TOC__
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[[Category: Satoo, K.]]
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</StructureSection>
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[[Category: Autophagy]]
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[[Category: Large Structures]]
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[[Category: E1]]
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[[Category: Saccharomyces cerevisiae S288C]]
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[[Category: Metal binding protein]]
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[[Category: Inagaki F]]
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[[Category: Zinc binding]]
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[[Category: Noda NN]]
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[[Category: Satoo K]]

Current revision

Crystal structure of Saccharomyces cerevisiae Atg7 (1-613)

PDB ID 3vh2

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